About 7 results found for searched term "Tetrabenazine" (0.077 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3252 | Tetrabenazine | Monoamine Transporter |
| Xenazine | ||
| Tetrabenazine (Nitoman, Xenazine) is a compound for the symptomatic treatment of hyperkinetic movement disorder. | ||
| M6184 | Dutetrabenazine | Others |
| Tetrabenazine D6; Ro 1-9569 D6 | ||
| Deutetrabenazine is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. | ||
| M14234 | NBI-98782 | Monoamine Oxidase |
| (+)-DTBZ; (+)-α-Dihydrotetrabenazine; (+)-α-DHTBZ | ||
| NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM. | ||
| M20395 | Tetrabenazine (Xenazine) | Dopamine Receptor |
| Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2 Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2. | ||
| M27659 | (+)-Tetrabenazine | Monoamine Transporter |
| (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine | ||
| (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2] | ||
| M30533 | Tetrabenazine Racemate | Monoamine Transporter |
| Ro 1-9569 Racemate | ||
| Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2). (1) The reference for administration is 0.25-0.75 mg/kg IP (2) Injections of tetrabenazine into accumbens core also reduced FR5 lever pressing and increased chow intake. (3) Tetrabenazine (Racemate) reduced extracellular DA and altered DARPP-32 signaling in both substance-P- and enkephalin-containing accumbens neurons. (4) Tetrabenazine (Racemate) inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice. | ||
| M30634 | Tetrabenazine mesylate | Monoamine Transporter |
| Ro 1-9569 mesylate | ||
| Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease. | ||
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