About 14 results found for searched term "Telomerase" (0.177 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1676 | BIBR1532 | Checkpoint |
| BIBR1532 is a potent and selective telomerase inhibitor with IC50 of 93 nM. | ||
| M6528 | BRACO-19 trihydrochloride | DNA/RNA Synthesis |
| BRACO-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. | ||
| M7195 | RHPS 4 methosulfate | Others |
| RHPS 4 methosulfate is a telomerase inhibitor. | ||
| M7925 | MST-312 | Telomerase |
| MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG) and a telomerase inhibitor. It can be used in the study of tumors such as multiple myeloma (MM). | ||
| M8490 | 6-Thio-2′-Deoxyguanosine | DNA/RNA Synthesis |
| 6-thio-dG; β-TGdR | ||
| 6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. | ||
| M11526 | Cycloastragenol | Telomerase |
| Astramembrangenin; Cyclosieversigenin | ||
| Cycloastragenol (Astramembrangenin) is the active form of Astragaloside IV and has antioxidant, anti-inflammatory, anti-aging, anti-apoptotic and cardiovascular protective effects. Cycloastragenol is an effective telomerase activator that lengthens telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties. | ||
| M11527 | BCH001 | DNA/RNA Synthesis |
| 3-Quinolinecarboxylic acid | ||
| BCH001 is a quinoline derivative and a selective PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in pluripotent stem cells induced by congenital keratosis (DC). BCH001 did not inhibit poly (A) -specific ribonucase (PARN) or several other polynucleotide polymerases. PAPD5 is A nonnormalized Poly (A) polymerase with an unconventional RNA binding motif. | ||
| M13665 | 360A iodide | Others |
| 360 A iodide | ||
| 360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay. | ||
| M13668 | TMPyP4 tosylate | DNA/RNA Synthesis |
| TMP 1363 | ||
| TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand, which inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines. | ||
| M49423 | Imetelstat | Telomerase |
| Imetelstat is a potentially first-in-class (first-in-class) telomerase inhibitor that competitively inhibits telomerase activity by targeting the telomerase RNA template. | ||
| M29876 | Epitalon | Telomerase |
| Epithalon; Epithalamin | ||
| Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa. | ||
| M30620 | 360A | DNA/RNA Synthesis |
| 360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay. | ||
| M31009 | Epitalon TFA | Telomerase |
| Epithalon TFA; Epithalamin TFA | ||
| Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa. | ||
| M50239 | Tertomotide hydrochloride | HSP |
| GV1001 | ||
| Tertomotide hydrochloride is a peptide consisting of 16 amino acids containing sequences derived from human telomerase reverse transcriptase (TERT).Tertomotide penetrates cells and interacts with HSP70 and HSP90, as well as inhibiting amyloid beta and tau, and inhibiting aging-related signaling in the brain. pathways, which could be used in aging and Alzheimer's disease related studies. | ||
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