About 4 results found for searched term "TNKS1/2-IN-2" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41576 | TNKS1/2-IN-2 | PARP |
| TNKS1/2-IN-2 is a potent and selective tankyrases inhibitor. | ||
| M5267 | E7449 | PARP |
| Stenoparib; 2X-121; MGI25036 | ||
| E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | ||
| M21589 | OM-153 | PARP |
| OM-153 is a potent, orally active tankyrase inhibitor with IC50 of 13 nM for tankyrase 1 and 2 nM for tankyrase 2 (TNKS1/2). OM-153 inhibited luciferase based Wnt/β-catenin signal transduction reporter activity with IC50 of 0.63 nM. OM-153 inhibits Wnt/β-catenin signal transduction and proliferation in COLO 320DM. | ||
| M30744 | TC-E 5001 | PARP |
| TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively. | ||
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