About 25 results found for searched term "STAT3-IN-8" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42102 | STAT3-IN-18 | JAK |
| STAT3-IN-18 is a platinum (IV) complex with an axial ligand derived from sandalwood. | ||
| M49687 | STAT3-IN-8 | STAT |
| STAT3-IN-8 is a potent STAT3 inhibitor. | ||
| M1782 | NSC 74859 (S3I-201) | STAT |
| S3I-201 | ||
| NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM. NSC 74859 (S3I-201) is effective in hepatocellular cancers with disrupted TGF-beta signaling.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M9217 | Givinostat | HDAC |
| ITF2357 | ||
| Givinostat (ITF-2357) is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. | ||
| M2111 | Fimepinostat | HDAC |
| CUDC-907 | ||
| Fimepinostat (CUDC-907) is a potent, orally-available small molecule dual PI3K and HDAC inhibitor, with IC50 values of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10, respectively. | ||
| M2537 | Cobicistat | Cytochrome P450 (e.g. CYP17) |
| GS-9350 | ||
| Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. | ||
| M5795 | Molidustat (BAY 85-3934) | HIF |
| BAY 85-3934 | ||
| Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. | ||
| M5807 | Napabucasin (BBI608) | STAT |
| BBI608; BB608 | ||
| Napabucasin (BBI608) is a first-in-class, orally active inhibitor of Stat3 that blocks stem cell activity in cancer cells by targeting the signal transducer and activator of transcription 3 pathway. Napabucasin inhibits cell proliferation of U87MG tumor xenografts in mice. | ||
| M7647 | Bryostatin 1 | PKC |
| Bryostatin 1 is a natural macrolide isolated from the moss bug Bugula neritina and a potent PKC modulator of central nervous system (CNS) permeability.Bryostatin 1 binds to the isolated Munc13-1 C1 domain and the full-length Munc13-1 protein with a Ki value of 8.07 and 0.45 nM, respectively, and has anticancer, anti-inflammatory and neuroprotective activities. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Ki values of 8.07 nM and 0.45 nM, respectively, and exhibits anticancer, anti-inflammatory, and neuroprotective activities. | ||
| M9386 | Verubecestat (MK-8931) | BACE |
| MK-8931 | ||
| Verubecestat (MK-8931) is an orally active, high-affinity (beta-secretase 1) BACE1 and BACE2 inhibitor, with Ki values of 2.2 nM and 0.38 nM, respectively. | ||
| M9769 | BP-1-102 | STAT |
| BP1102 | ||
| BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor with IC50 of 6.8 μM. | ||
| M13678 | Resminostat hydrochloride | HDAC |
| RAS2410 hydrochloride; 4SC-201 hydrochloride | ||
| Resminostat hydrochloride is a potent inhibitor of HDAC1, HDAC3 and HDAC6, with mean IC50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC50 of 877 nM. | ||
| M14148 | STAT3-IN-1 | STAT |
| STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. | ||
| M20389 | Quisinostat (JNJ-26481585) 2HCl | HDAC |
| Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11 greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. | ||
| M21510 | Telaglenastat hydrochloride | Others |
| CB-839 hydrochloride | ||
| Telaglenastat (CB-839) hydrochloride is a pioneering (first-in-class), selective, reversible, orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride has IC50 values of 23 nM and 28 nM for endogenous glutaminase in the kidney and brain of mice, respectively. Telaglenastat hydrochloride also induces autophagy and has strong antitumor activity. | ||
| M21677 | Recombinant Human Follistatin 288 (HEK293, C-6His) | Cytokines and Growth Factors |
| FST; follistatin isoform FST317 | ||
| Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Recombinant Human Follistatin/FST is produced by Mammalian expression system and the target gene encoding Gly30-Asn317 is expressed with a 6His tag at the C-terminus. | ||
| M28064 | Nanatinostat | HDAC |
| CHR-3996 | ||
| Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. | ||
| M28987 | Quabodepistat | Antibiotic |
| OPC-167832 | ||
| Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with an IC50 of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis. | ||
| M29087 | Givinostat hydrochloride | HDAC |
| ITF-2357 hydrochloride | ||
| Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. | ||
| M29380 | Y06137 | Epigenetic Reader Domain |
| Y06137 is a potent and selective BET inhibitor for treatment of castration-resistant prostate cancer (CRPC). Y06137 binds to the BRD4(1) bromodomain with a Kd of 81 nM. | ||
| M30649 | C188 | STAT |
| CPD188 | ||
| C188 is a STAT3 inhibitor that inhibits IL-6-stimulated STAT3 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket. C188, in particular, was highly active in inducing apoptosis of the breast cancer cell line MB-MDA-468 in vitro (EC50= 0.7 μM). | ||
| M42633 | Verubecestat TFA | Gamma-secretase/Beta-secretase |
| Verubecestat (MK-8931) TFA is an orally active, high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2 nM and 0.38 nM. | ||
| M49655 | HP590 | STAT |
| HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). | ||
| M49678 | STAT3-IN-10 | STAT |
| STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 µM. | ||
| M56430 | HP590 | STAT |
| HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). | ||
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