About 8 results found for searched term "SK1-I hydrochloride" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5136 | GSK-LSD1 dihydrochloride | Histone demethylase |
| GSK-LSD1 2HCl | ||
| GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). | ||
| M13396 | SK1-I hydrochloride | SPHK |
| BML-258 hydrochloride | ||
| SK1-I hydrochloride (BML-258 hydrochloride), an analogue of sphingine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 µM. | ||
| M30118 | Aplaviroc hydrochloride | CCR |
| AK602 hydrochloride; GSK-873140 hydrochloride; GW-873140 hydrochloride | ||
| Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. | ||
| M57216 | GSK143 dihydrochloride | Syk |
| GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. | ||
| M6594 | CHIR 99021 trihydrochloride | GSK-3 |
| Laduviglusib trihydrochloride; CT99021 trihydrochloride | ||
| Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. | ||
| M20750 | A2764 dihydrochloride | Potassium Channel |
| A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception. | ||
| M30720 | Mirodenafil dihydrochloride | PDE |
| SK-3530 dihydrochloride | ||
| Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc). | ||
| M39836 | Manzamine A hydrochloride | GSK-3 |
| Manzamine A hydrochloride inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride also shows potent activity against HSV-1. | ||
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