About 14 results found for searched term "SHIN1" (0.134 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14767 | SHIN1 | Transferase |
| RZ-2994 | ||
| SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. | ||
| M14768 | (+)-SHIN1 | Others |
| (+)-RZ-2994 | ||
| (+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1. | ||
| M14769 | (-)-SHIN1 | Others |
| (-)-RZ-2994 | ||
| (-)-SHIN1 ((-)-RZ-2994) is an inactive (−) enantiomer of SHIN1. | ||
| M58693 | BSH-IN-1 | Antibiotic |
| BSHIN1 | ||
| BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively. | ||
| M14154 | Magnolin | ERK |
| Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively. | ||
| M19363 | Parishin | Others |
| Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway. | ||
| M29216 | Isotanshinone IIA | Phosphatase |
| Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. | ||
| M29345 | (Rac)-SHIN2 | Others |
| (Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively. | ||
| M30600 | 1,2-Dihydrotanshinone | Others |
| 1,2-Dihydrotanshinquinone | ||
| 1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1. | ||
| M38950 | Tanshindiol C | Histone Methyltransferase |
| Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. | ||
| M39188 | Deoxyneocryptotanshinone | BACE |
| Deoxyneocryptotanshinone is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. | ||
| M40308 | Isoshinanolone | Others |
| Isoshinanolone is a natural product that can be extracted from Plumbago capensis. Isoshinanolone has mosquito larvicidal activity against fourth instar larvae of A. aegypti, with an IC50 value of 1.26 μg/mL. | ||
| M40344 | Tanshindiol B | Others |
| Tanshindiol B, a naphthaquinone diterpene, inhibits GBM growth by induction of noptosis (NQO1-dependent necrosis). | ||
| M44934 | Methyl tanshinonate | Anti-infection |
| Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 µM). | ||
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