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(-)-SHIN1

Cat. No. M14769
(-)-SHIN1 Structure
Synonym:

(-)-RZ-2994

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Biological Activity

(-)-SHIN1 ((-)-RZ-2994) is an inactive (−) enantiomer of SHIN1.

Chemical Information
Molecular Weight 400.47
CAS Number 2444764-09-2
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Long He, et al. Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells

[2] Yun Zhang, et al. SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells

[3] Thanh H Nguyen, et al. Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification

[4] Nayab Batool, et al. Functional Identification of Serine Hydroxymethyltransferase as a Key Gene Involved in Lysostaphin Resistance and Virulence Potential of Staphylococcus aureus Strains

[5] Shinichi Mizuno, et al. Amyloid cast nephropathy with systemic AL amyloidosis

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Keywords: (-)-SHIN1, (-)-RZ-2994 supplier, inhibitors, activators

 
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