About 32 results found for searched term "SCS" (0.096 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42177 | SCS | GABA Receptor |
| SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. | ||
| M55654 | Kyoto probe 1 | Fluorescent Dye |
| KP-1 | ||
| Kyoto probe 1 is a hiPSCs fluorescent probe. Kyoto probe 1 selectively labels human pluripotent stem cells. Kyoto probe 1 is primarily explained by the distinct expression patterns of ATP-binding cassette (ABC) transporters by hiPS cells and differentiated cells. Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. | ||
| M2445 | Benztropine mesylate | Dopamine Receptor |
| Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate | ||
| Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. Benztropine mesylate is a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects. Benztropine mesylate is also an anti-histamine agent and a dopamine re-uptake inhibitor. | ||
| M2563 | NSC 14613 | Dehydrogenase |
| NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs. | ||
| M4577 | Segetalin-B | Peptides |
| Segetalin-B is an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. | ||
| M21540 | L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) | Phosphatase |
| L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) is a long-term vitamin C derivative that can stimulate the expression and formation of collagen. L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) can be used as a medium to supplement osteogenic differentiation of human adipose stem cells (hASCs). Increased alkaline phosphatase (ALP) activity and runx2A expression in hASC during osteoblast differentiation. | ||
| M5625 | Estradiol | Estrogen Receptor |
| β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol | ||
| Estradiol (17β-estradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (17β-estradiol) can be used to construct animal models of chronic non-bacterial prostatitis. | ||
| M5875 | Phenytoin | Sodium Channel |
| Diphenylhydantoin; 5,5-Diphenylhydantoin | ||
| Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin reduces breast tumour growth and metastasis in mice, and it also has antiepileptic activity. | ||
| M5876 | Phenytoin Sodium | Sodium Channel |
| Diphenylhydantoin Sodium | ||
| Phenytoin Sodium is a potent Voltage-gated Na+ channels (VGSCs) blocker. | ||
| M6609 | CITCO | Others |
| CITCO is a selective Constitutive androstane receptor (CAR) agonist. CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR). | ||
| M6802 | I-BET 151 dihydrochloride | Others |
| I-BET 151 dihydrochloride is a bET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes. | ||
| M6814 | IDE 1 | Others |
| IDE1 | ||
| IDE 1 is a induces definitive endoderm formation in mouse and human ESCs. | ||
| M6815 | IDE 2 | Others |
| IDE 2 is a induces definitive endoderm formation in mouse and human ESCs. | ||
| M6835 | IQ 1 | Wnt/beta-catenin |
| IQ 1 is a enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation. | ||
| M7437 | TWS 119 Trifluoroacetate | Others |
| TWS 119 Trifluoroacetate is a gSK-3β inhibitor; induces neuronal differentiation in ESCs. | ||
| M7463 | Veratridine | Sodium Channel |
| 3-Veratroylveracevine | ||
| Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. | ||
| M10039 | GsMTx4 | Peptides |
| GsMTx-4 | ||
| GsMTx4 is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. | ||
| M10875 | PluriSIn #2 | Topoisomerase |
| PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs). | ||
| M14448 | Echinomycin | HIF |
| Quinomycin A; NSC-13502 | ||
| Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM. | ||
| M14745 | NSC23005 sodium | Others |
| NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. | ||
| M20774 | CTPI-2 | Mitochondrial Related |
| CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). | ||
| M21385 | Avdoralimab | Others |
| anti-hC5aR-32F3A6 GL;IPH-5401 | ||
| Avdoralimab (IPH5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1, and blocks C5a/C5aR1 signalling in subsets of myeloid-derived suppressor cells (MDSCs) and neutrophils. It has immunomodulating activity. | ||
| M21809 | SJA710-6 | Others |
| SJA-710-6 | ||
| SJA710-6 is a small molecule able to selectively differentiate MSCs toward hepatocyte-like cells. | ||
| M24835 | Cusatuzumab | Apoptosis |
| ARGX-110 | ||
| Cusatuzumab is a human αCD70 monoclonal antibody. Cusatuzumab shows cytotoxicity activity with enhanced antibody-dependent cellular. Cusatuzumab reduces leukemia stem cells (LSCs) and triggers gene signatures related to myeloid differentiation and apoptosis. Cusatuzumab has the potential for the research of Acute myeloid leukemia (AML). | ||
| M29222 | Yhhu-3792 | Notch |
| Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction. | ||
| M29535 | cRIPGBM | RIPK |
| cRIPGBM, a proapoptotic derivative of RIPGBM, a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to receptor-interacting protein kinase 2 (RIPK2), with an EC50 of 68 nM in GBM-1 cells. | ||
| M29536 | cRIPGBM chloride | RIPK |
| cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models. | ||
| M29685 | SU16f | VEGFR/PDGFR |
| SU16f is a potent and selective PDGFRβ inhibitor with IC50s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively. Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration. | ||
| M29971 | RIPGBM | Apoptosis |
| RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM. | ||
| M30625 | KLD-12 | Peptides |
| KLD-12 is a 12-residue self-assembling peptide that can enhance chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair. | ||
| M30719 | Benztropine | Dopamine Receptor |
| Benzatropine; Benzotropine | ||
| Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects. | ||
| M30737 | Mesendogen | TRP Channel |
| Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development. | ||
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