About 1 result found for searched term "Rubone " (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30559 | Rubone | MicroRNA (miRNA) |
| Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhanced the anticancer effect of Paclitaxel (PTX) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets. | ||
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