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Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhanced the anticancer effect of Paclitaxel (PTX) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets.
| Molecular Weight | 374.38 |
| Formula | C20H22O7 |
| CAS Number | 73694-15-2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[3] Zhangang Xiao, et al. Mol Cell Oncol. Small molecule targeting miR-34a for cancer therapy
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