About 6 results found for searched term "Reserpine" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4663 | Reserpine | Animal Modeling |
| Reserpine is an inhibitor of vesicular monoamine transporter protein 2 (VMAT2) that irreversibly blocks the H+-coupled vesicular monoamine transporters, VMAT1 and VMAT2. It can be used to construct animal models of depression. | ||
| M14235 | Reserpine hydrochloride | Monoamine Oxidase |
| Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). | ||
| M8729 | Syrosingopine | Others |
| Syrosingopine is an antihypertensive agent related to reserpine that was found to potentiate the anticancer effects of the antidiabetic agent metformin and phenformin without harmful effects on normal cells. | ||
| M14379 | L-5-Hydroxytryptophan | Metabolite/Endogenous Metabolite |
| L-5-HTP; Oxitriptan | ||
| L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. | ||
| M27659 | (+)-Tetrabenazine | Monoamine Transporter |
| (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine | ||
| (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2] | ||
| M56591 | Deserpidine | ACE |
| Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. | ||
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