About 8 results found for searched term "RO-7 " (0.053 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27714 | RO5166017 | TAAR |
| RO5166017 is an orally active and species-crosses TAAR1 agonist, with Ki values of 1.9 nM, 2.7 nM, 31 nM and 24 nM for mouse, rat, human and cynomolgus monkey, respectively. | ||
| M27810 | NecroX-7 | HMGB1 |
| NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research. | ||
| M28237 | RO5263397 | TAAR |
| RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect. | ||
| M28269 | RO-7 | Anti-infection |
| RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses. | ||
| M29635 | PROTAC IRAK4 degrader-7 | PROTAC |
| KT-474; SAR444656 | ||
| PROTAC IRAK4 degrader-7 (Compound I-417) is a potentially first-in-class, orally active PROTAC IRAK4 degrader with antitumor activity for studies related to hidradenitis suppurativa (HS) and atopic dermatitis (AD). | ||
| M30087 | Dehydro-ZINC39395747 | Others |
| Dehydro-ZINC39395747 is a derivative of ZINC39395747. ZINC39395747 is a potent cytochrome b5 reductase 3 (CYB5R3) inhibitor with an IC50 of 9.14 μM and a Kd of 1.11 μM. ZINC39395747 can increase NO bioavailability in vascular cells. | ||
| M30585 | 4-Bromo A23187 | Calcium Channel |
| 4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187，a calcium modulator, induces apoptosis in different cells, including HL-60 cells. | ||
| M55813 | RO-9187 | Anti-infection |
| RO-9187 is a potent inhibitor of HCV virus replication with an IC50 of 171 nM. | ||
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