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RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect.
| Molecular Weight | 194.21 |
| Formula | C10H11FN2O |
| CAS Number | 1357266-05-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 260 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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