Ulotaront HCl is a first-in-class, orally active, CNS-active TAAR1 agonist for studies related to schizophrenia.
| Molecular Weight | 219.73 |
| Formula | C9H14ClNOS |
| CAS Number | 1310422-41-3 |
| Form | Solid |
| Solubility (25°C) | Water 100 mg/mL DMSO 62.5 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| RO5263397
RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect. |
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| Ulotaront
Ulotaront (SEP-856) is a first-in-class, orally active, CNS-active TAAR1 agonist for use in studies related to schizophrenia. |
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