RO-275 - Search Results | AbMole BioScience

About 5 results found for searched term "RO-275" (0.129 seconds)

Cat.No.	Name	Target
M3483	Flavopiridol hydrochloride	CDK
	NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl
	Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA.
M13520	Ro 08-2750	Apoptosis
	Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC₅₀ of ~ 1 µM.
M55627	RO-275	HCN Channel
	RO-275 is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. The selective HCN1 inhibitor RO-275 improved performance in a translationally relevant touchscreen task of WM (TUNL) in rats.
M6082	2,6-Dichloro-3,5-dimethoxyaniline	Others
	2,6-Dichloro-3,5-dimethoxyaniline is H3B-6275 intermediate.
M50214	AC 187 TFA	Amyloid
	AC 187 TFA is a potent, orally active and neuroprotective amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA is more selective for amylin receptors than calcitonin and CGRP receptors.