About 3 results found for searched term "RO-275" (0.08 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3483 | Flavopiridol hydrochloride | CDK |
| NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl | ||
| Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. | ||
| M13520 | Ro 08-2750 | Apoptosis |
| Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. | ||
| M55627 | RO-275 | HCN Channel |
| RO-275 is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. The selective HCN1 inhibitor RO-275 improved performance in a translationally relevant touchscreen task of WM (TUNL) in rats. | ||
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