About 4 results found for searched term "R112" (0.355 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8199 | SR11237 | RAR/RXR |
| SR11237 is a retinoid X receptor (RXR) selective agonist without any RAR activity that leads to the formation of RXR/RXR homodimers and activation of reporter genes containing RXR response elements. In addition, SR11237 significantly promotes reprogramming. | ||
| M8764 | MM11253 | RAR/RXR |
| SR11253 | ||
| MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARα, RARβ, RXRα). | ||
| M9012 | R112 | Syk |
| R112 is an ATP-competitive inhibitor of Syk kinase with an IC50 of 226 nM. | ||
| M27980 | DBPR112 | EGFR/HER2 |
| DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 can occupy the ATP-binding site. DBPR112 has significant antitumor efficacy. | ||
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