About 9 results found for searched term "PI3K-IN-47" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5343 | Voxtalisib Analogue | PI3K |
| PI3K-IN-1; XL-147 derivative 1; SAR245409 | ||
| PI3K-IN-1 (XL-147 derivative 1) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | ||
| M43391 | PI3K-IN-47 | PI3K |
| PI3K-IN-47 is a bivalent PI3K inhibitor (IC50: 0.44 nM for PI3Kα, 7.18 nM, 13.92 nM, 22.83 nM for PI3Kβ, PI3Kγ, PI3Kδ). | ||
| M1984 | PF-04691502 | PI3K |
| PF-04691502 is a potent and selective, ATP-competitive PI3K/mTOR inhibitor with IC50 of 7.5 nM and 3.8 nM of AKT T308 and AKT S473, respectively. | ||
| M3218 | PKI-402 | PI3K |
| PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM, respectively; also potent to PI3Kα mutants E545K and H1047R. | ||
| M13754 | OSU-T315 | Integrin |
| OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). | ||
| M20610 | AMG319 | PI3K |
| AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. | ||
| M43388 | PI3Kγ inhibitor 7 | PI3K |
| PI3Kγ inhibitor 7 is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. | ||
| M49898 | SNV4818 | PI3K |
| SNV4818 is a potential best-in-class (best-in-class) mutation-selective PI3K-α inhibitor with excellent selectivity for the H1047X mutant and moderate selectivity for the related E545/542X mutant. | ||
| M57078 | PI3Kα-IN-22 | PI3K |
| PI3Kα-IN-22 is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. | ||
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