About 10 results found for searched term "PDK-IN-1" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21648 | PDK4-IN-1 hydrochloride | Apoptosis |
| PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. | ||
| M42534 | PDK-IN-1 | PDHK |
| PDK-IN-1 is a pyruvate dehydrogenase kinase (PDK) inhibitor. | ||
| M42593 | PKM2/PDK1-IN-1 | Pyruvate Kinase |
| PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of PKM2/PDK1. | ||
| M2310 | BX-795 | PDK1 |
| BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively. | ||
| M2311 | BX-912 | PDK1 |
| BX912 is a selective potent PDK1 inhibitor with IC50 of 12 nM. | ||
| M4832 | NVP-BAG956 | PDK1 |
| BAG956 | ||
| NVP-BAG956 is a potent, ATP-competitive and selective dual PDK1 and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). | ||
| M7989 | PS48 | Others |
| PS48 is a PDK1 (phosphoinositide-depende |
||
| M20816 | PS210 | PDK1 |
| PS210 is a potent activator of PDK1 that binds to the PIF-pocket and allosterically modulates the active site of PDK1. | ||
| M28603 | PS10 | PDHK |
| PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM). PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy.PDK: pyruvate dehydrogenase kinase | ||
| M28769 | PDK1-IN-RS2 | PDK1 |
| PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1. | ||
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