About 6 results found for searched term "PCNA-I1" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M11539 | PCNA-I1 | DNA/RNA Synthesis |
| Pcna-i1 is an effective PCNA (proliferating cell nuclear antigen) inhibitor. Pcna-i1 can selectively bind PCNA trimers, and its Kd value ranges from 0.2 μM to 0.4 μM. Pcna-i1 inhibited the growth of tumor cells with an IC50 value of ~0.2 μM. | ||
| M28293 | T2AA | DNA/RNA Synthesis |
| T2 amino alcohol | ||
| T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase. | ||
| M40519 | AOH1996 | DNA/RNA Synthesis |
| AOH1996 is an orally active small molecule PCNA inhibitor, which can be obtained by adding a methoxy group to the interstitial position of the benzene ring at the end of AOH1160, and enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II, as well as selectively kills cancer cells, which can be used in cancer-related research. | ||
| M40720 | I-138 | Deubiquitinase |
| I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. | ||
| M40722 | H-Ile-Lys-Val-Ala-Val-OH | ERK |
| H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1, which promotes cell adhesion, neurite growth, and tumor growth. It also stimulates BMSC cell growth and proliferation and proliferating cell nuclear antigen (PCNA) synthesis by activating the MAPK/ERK1/2 and PI3K/Akt signaling pathways. | ||
| M40723 | Recombinant Human KIAA0101 Protein (E. coli, His) | Cytokines and Growth Factors |
| p15/PAF Protein; OEATC-1 | ||
| KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). KIAA11 is involved in cell proliferation and plays a role in early tumor recurrence (ETR), and prognosis of hepatocellular carcinoma (HCC). | ||
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