Free shipping on all orders over $ 500
About 30 results found for searched term "Nrf2" (0.017 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M2198 | Curcumin | Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. |
| M2432 | Bardoxolone Methyl | Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. |
| M4072 | Ginsenoside-Rh3 | Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 induces Nrf2 activation in human retinal cells. |
| M4428 | Senkyunolide-I | Senkyunolide I can be isolated from Ligusticum chuanxiong Hort and is an antimigraine compound. Senkyunolide I protects rat brain from focal cerebral ischemia-perfusion injury by up-regulating P-ERK1/2, Nrf2/HO-1 and inhibiting Caspase 3. |
| M4443 | Spinosin | Spinosyn is a neuroprotective C-glycoside flavonoid isolated from the seeds of Zizyphus jujube. Spinosyn inhibits the production and polymerization of Aβ1-42 by activating the Nrf2/HO-1 pathway. |
| M4481 | Mangiferin | Mangiferin is an Nrf2 activator. Mangiferin inhibits nuclear translocation of NF-κB subunit P65 and P50. Mangiferin has antioxidant, anti-diabetic, anti-hyperuricemia, antiviral, anticancer and anti-inflammatory activities. |
| M4551 | Trigonelline-Hydrochloride | As an NRF2 inhibitor, fenuelline blocks the expression of NRF2 target genes associated with heme and iron metabolism, synergistic with Erastin and sorafenib to promote iron death in hepatocellular carcinoma cells. |
| M4588 | Astilbin | Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation. |
| M4589 | Luteolin | Luteolin (Luteoline) is a flavanoid that can induce cell apoptosis and cell cycle arrest in several cancer cell lines. Luteolin (Luteoline) is also a potent Nrf2 inhibitor. |
| M4686 | Eriodictyol | Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM. |
| M4697 | (+)-Corynoline | Corynoline is a reversible and non-competitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM. Corynoline acts as an anti-inflammatory by activating Nrf2. |
| M4751 | 5,7-dihydroxychromone | 5,7-dihydroxychromone is a natural antioxidant extracted from plants, it acts as an Nrf2/ARE signal activator or a PPARγ agonist. |
| M5238 | Bardoxolone | Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. |
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M5580 | Dimethyl Fumarate | Dimethyl fumarate(DMF) is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. |
| M5834 | Oltipraz | Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). |
| M5927 | Retinoic acid | Retinoic acid is A metabolite of vitamin A and plays an important role in cell growth, differentiation and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors with an IC50 of 14 nM for RARα/β/γ. The Kd value of Retinoic acid combined with PPARβ/δ is 17 nM. Retinoic acid inhibits the transcription factor Nrf2 by activating Retinoic acid receptors. |
| M6296 | Pyridoxine | Pyridoxine ((Pyridoxol, Vitamin B6, Gravidox)) is a pyridine derivative. Pyridoxine acts on alzheimer's disease cell models and exerts antioxidant effects through the NRF-2 /HO-1 pathway. |
| M6418 | AI-3 | AI-3 is a aRE activator; induces Nrf2-ARE-dependent transcription. |
| M6976 | ML 334 | ML 334 is a inhibitor of Keap1- Nrf2 interaction. |
| M6985 | MMF | MMF is a activator of Nrf2 pathway; primary metabolite of DMF. |
| M7182 | RA 839 | RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction. |
| M8348 | 2-HBA (HBB2) | 2-HBA (HBB2) is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups. |
| M8692 | ML385 | ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1. |
| M8733 | K67 | K67 is a specific inhibitor against the interaction between KEAP1 (Kelch-like ECH-associated protein 1) DC (double glycine repeat and C-terminal region) domain and S349-phosphorylated (human Ser349, mouse Ser351) KIR (Keap1-interacting region) of p62/SQSTM1, thereby preventing phospho-p62 from blocking KEAP1-DC and NRF2 (nuclear factor erythroid 2-related factor 2) DLGex motif association. |
| M8767 | MIND4-17 | MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. |
| M8807 | Perillaldehyde | Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. |
| M8891 | AI-1 | AI-1 is a negative regulator of Nrf2. |
| M9059 | TBHQ | TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator. |
| M9140 | Hinokitiol | Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
