Free shipping on all orders over $ 500

 About 30 results found for searched term "Nrf2" (0.017 seconds)

Cat.No.  Name Information
M2198 Curcumin Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification.
M2432 Bardoxolone Methyl Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
M4072 Ginsenoside-Rh3 Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 induces Nrf2 activation in human retinal cells.
M4428 Senkyunolide-I Senkyunolide I can be isolated from Ligusticum chuanxiong Hort and is an antimigraine compound. Senkyunolide I protects rat brain from focal cerebral ischemia-perfusion injury by up-regulating P-ERK1/2, Nrf2/HO-1 and inhibiting Caspase 3.
M4443 Spinosin Spinosyn is a neuroprotective C-glycoside flavonoid isolated from the seeds of Zizyphus jujube. Spinosyn inhibits the production and polymerization of Aβ1-42 by activating the Nrf2/HO-1 pathway.
M4481 Mangiferin Mangiferin is an Nrf2 activator. Mangiferin inhibits nuclear translocation of NF-κB subunit P65 and P50. Mangiferin has antioxidant, anti-diabetic, anti-hyperuricemia, antiviral, anticancer and anti-inflammatory activities.
M4551 Trigonelline-Hydrochloride As an NRF2 inhibitor, fenuelline blocks the expression of NRF2 target genes associated with heme and iron metabolism, synergistic with Erastin and sorafenib to promote iron death in hepatocellular carcinoma cells.
M4588 Astilbin Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation.
M4589 Luteolin Luteolin (Luteoline) is a flavanoid that can induce cell apoptosis and cell cycle arrest in several cancer cell lines. Luteolin (Luteoline) is also a potent Nrf2 inhibitor.
M4686 Eriodictyol Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM.
M4697 (+)-Corynoline Corynoline is a reversible and non-competitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM. Corynoline acts as an anti-inflammatory by activating Nrf2.
M4751 5,7-dihydroxychromone 5,7-dihydroxychromone is a natural antioxidant extracted from plants, it acts as an Nrf2/ARE signal activator or a PPARγ agonist.
M5238 Bardoxolone Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.
M5301 (E)-Cardamonin (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
M5580 Dimethyl Fumarate Dimethyl fumarate(DMF) is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression.
M5834 Oltipraz Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST).
M5927 Retinoic acid Retinoic acid is A metabolite of vitamin A and plays an important role in cell growth, differentiation and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors with an IC50 of 14 nM for RARα/β/γ. The Kd value of Retinoic acid combined with PPARβ/δ is 17 nM. Retinoic acid inhibits the transcription factor Nrf2 by activating Retinoic acid receptors.
M6296 Pyridoxine Pyridoxine ((Pyridoxol, Vitamin B6, Gravidox)) is a pyridine derivative. Pyridoxine acts on alzheimer's disease cell models and exerts antioxidant effects through the NRF-2 /HO-1 pathway.
M6418 AI-3 AI-3 is a aRE activator; induces Nrf2-ARE-dependent transcription.
M6976 ML 334 ML 334 is a inhibitor of Keap1- Nrf2 interaction.
M6985 MMF MMF is a activator of Nrf2 pathway; primary metabolite of DMF.
M7182 RA 839 RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction.
M8348 2-HBA (HBB2) 2-HBA (HBB2) is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups.
M8692 ML385 ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1.
M8733 K67 K67 is a specific inhibitor against the interaction between KEAP1 (Kelch-like ECH-associated protein 1) DC (double glycine repeat and C-terminal region) domain and S349-phosphorylated (human Ser349, mouse Ser351) KIR (Keap1-interacting region) of p62/SQSTM1, thereby preventing phospho-p62 from blocking KEAP1-DC and NRF2 (nuclear factor erythroid 2-related factor 2) DLGex motif association.
M8767 MIND4-17 MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2.
M8807 Perillaldehyde Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.
M8891 AI-1 AI-1 is a negative regulator of Nrf2.
M9059 TBHQ TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator.
M9140 Hinokitiol Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.