About 10 results found for searched term "NT157" (0.135 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M20615 | NT157 | IGF-1R |
| NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival. | ||
| M1749 | Gefitinib | EGFR/HER2 |
| ZD-1839, Iressa | ||
| Gefitinib (ZD1839) is an EGFR tyrosine kinase and Akt phosphorylation inhibitor. Gefitinib significantly down-regulates CD47 expression and increases DC phagocytosis in non-small cell lung cancer cells such as PC9, H1437 and H1573. Gefitinib combined with CD47 antibody can enhance the phagocytosis of macrophages. | ||
| M3643 | TMP269 | HDAC |
| TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.In addition, TMP269 significantly promotes reprogramming. | ||
| M10929 | Cedirogant | ROR |
| ABBV-157 | ||
| Cedirogant (ABBV-157) is an orally active RORγt reverse agonist that can be used in the study of psoriasis. | ||
| M11492 | Recombinant Human Endostatin (P. pastoris) | Recombinant Proteins |
| Endostatin | ||
| Recombinant human Endostatin protein (P. pastoris) is determined by the formation of endothelial cells. Endostatin concentration of 10 μg/ mL showed obvious anti-angiogenesis effect. Protein structure: Endostatin (ALA1571-Lys1754), Accession # P39060. | ||
| M13441 | Recombinant Human IFN-β (HEK 293) | Recombinant Proteins |
| Recombinant human IFN-β protein (HEK 293) acts through STAT1 and STAT2 and is known to up-regulate and down-regulate a number of genes, most of which are involved in antiviral immune responses. Protein structure: IFN-β (MET22-ASN187), Accession # P01574. | ||
| M21390 | Recombinant Mouse IFN alpha2 (E.coli) | Recombinant Proteins |
| Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A; LeIF A; IFNA2 | ||
| Recombinant Mouse Interferon Alpha-2 was produced by the E. coli expression system and the target gene encoding Cys24-Glu190 was expressed. Protein number: P01573. | ||
| M28283 | BPC 157 acetate | Metabolite/Endogenous Metabolite |
| BPC 157 acetate is a stable gastric pentadecapeptide and a partial sequence of the human gastric juice protein BPC. BPC 157 is an anti-ulcer peptidergic agent with no reported toxicity. BPC 157 links inflammatory bowel disease and multiple sclerosis. | ||
| M30871 | Tenofovir exalidex | HIV Protease |
| CMX-157 | ||
| Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV. | ||
| M49582 | JAK2/TYK2-IN-1 | JAK |
| JAK2/TYK2-IN-2 is a potent and selective TYK2 inhibitor with IC50 values of 9 and 157 nM for TYK2 and JAK2, respectively. | ||
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