About 3 results found for searched term "NLRP3-IN-18" (0.207 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42025 | NLRP3-IN-18 | NLR |
| NLRP3-IN-18 is a potent NLRP3 inhibitor with an IC50 value of ≤1.0 µM. | ||
| M10611 | QS-21 | Adjuvants |
| QS-21 ADJUVANT; Stimulon | ||
| QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18. | ||
| M30978 | Fc 11a-2 | NLR |
| Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS)-induced murine experimental colitis. | ||
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