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 About 12 results found for searched term "Mutant IDH1-IN-1" (0.097 seconds)

Cat.No.  Name Target
M14454 Mutant IDH1-IN-1 Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
M10335 IDH-305 Isocitrate Dehydrogenase (IDH)
IDH305
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1(R132) mutation with IC50 values of 27 nM, 28 nM and 6.14 μM for IDH1R132H, IDH1R132C and IDH1WT, respectively.
M10434 Olutasidenib (FT-2102) Isocitrate Dehydrogenase (IDH)
FT-2102
Olutasidenib (FT-2102) is a highly potent and selective, orally active, brain penetrant mutant Isocitrate dehydrogenase 1 (IDH1) inhibitor, with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively.
M11277 IDH889 Isocitrate Dehydrogenase (IDH)
IDH889 is an orally available, brain permeable, allosteric and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1). IDH889 showed high selectivity against IDH1R132 * mutant, with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM against IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 showed high inhibition of intracellular 2-Hg level with IC50 value of 0.014 μM.
M14455 Mutant IDH1-IN-2 Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.
M14456 Mutant IDH1 inhibitor Isocitrate Dehydrogenase (IDH)
Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.
M28461 AGI-12026 Dehydrogenase
AGI-026
AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma.
M28911 GSK321  Isocitrate Dehydrogenase (IDH)
GSK321 is a potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) enzymes. GSK321 has high inhibitory and selectivity for mutant IDH1 enzymes. GSK321 can be used for the research of acute myeloid leukemia.
M54530 (1R)-IDH889 Isocitrate Dehydrogenase (IDH)
(1R)-IDH889 is the inactive isomer of IDH889, which serves as a control compound in experiments.IDH889 is an orally active, brain-permeable, variant- and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1).IDH889 is highly selective for the IDH1 R132 mutant, and acts efficiently on IDH1R132H, IDH1R132C and IDH1wt with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM, respectively.In addition, IDH889 has a potent and potent effect on IDH1R132C and IDH1wt, IDH889 is highly selective for the IDH1 R132 mutant, with IC50 values of 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt, respectively, and has a high potency to inhibit the level of intracellular 2-HG, with an IC50 value of 0.014 μM.
M54531 (S,R)-GSK321 Isocitrate Dehydrogenase (IDH)
(S,R)-GSK321 is a potent and selective inhibitor of mutant IDH1, inhibiting R132G, R132C, R132H, and WT IDH1 with IC50 values of 2.9, 3.8, 4.6, and 46 nM, respectively, with a 100-fold higher selectivity than IDH2. (S,R)-GSK321 induces a reduction in intracellular 2-HG, failure of myeloid differentiation blockade, and induction of granulocyte differentiation at the level of leukemoblasts and more immature stem cells. (S,R)-GSK321 can be used in studies related to acute myeloid leukemia (AML) and other cancers.
M54535 IDH1 Inhibitor 1 Isocitrate Dehydrogenase (IDH)
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-permeable, selective mutant IDH1 inhibitor that inhibits IDH1R132H, IDH1R132C, and IDH1WT with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM, respectively. possesses antitumor activity.
M54537 Mutant IDH1-IN-4 Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-4 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH 1) with an IC50 value of ≤ 0.5 μM for mutant IDH 1 in R132H, HT1080 and U87R132H cells.



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