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GSK321 

Cat. No. M28911

All AbMole products are for research use only, cannot be used for human consumption.

GSK321  Structure

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Quality Control & Documentation
Biological Activity

GSK321 is a potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) enzymes. GSK321 has high inhibitory and selectivity for mutant IDH1 enzymes. GSK321 can be used for the research of acute myeloid leukemia.

Chemical Information
Molecular Weight 501.55
Formula C28H28FN5O3
CAS Number 1816331-63-1
Form Solid
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage 4°C, protect from light
References

[1] Wenting Dai, et al. Cell Mol Life Sci. Metabolic reprogramming in the OPA1-deficient cells

Related Isocitrate Dehydrogenase (IDH) Products
Mutant IDH1-IN-4

Mutant IDH1-IN-4 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH 1) with an IC50 value of ≤ 0.5 μM for mutant IDH 1 in R132H, HT1080 and U87R132H cells.

(S,S)-GSK321

(S,S)-GSK321 is the (S,S)-enantiomer of GSK321.GSK321 is a potent inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme.

IDH1 Inhibitor 1

IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-permeable, selective mutant IDH1 inhibitor that inhibits IDH1R132H, IDH1R132C, and IDH1WT with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM, respectively. possesses antitumor activity.

IDH1 Inhibitor 7

IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC50 of less than 100 nM.

(R,R)-GSK321

(R,R)-GSK321 is an isomer of GSK321 and a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: GSK321  supplier, Isocitrate Dehydrogenase (IDH), inhibitors, activators

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