About 5 results found for searched term "Mitoxantrone" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M3493 | Mitoxantrone | Topoisomerase |
| Mitozantrone; NSC 301739 | ||
| Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively | ||
| M28449 | Pixantrone free base | Topoisomerase |
| BBR 2778 free base | ||
| Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. | ||
| M28845 | Pixantrone hydrochloride | Topoisomerase |
| BBR 2778 hydrochloride | ||
| Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. | ||
| M30477 | 6,8-Diprenylnaringenin | BCRP/ABCG2/MXR/ABCP |
| Lonchocarpol A; Senegalensin | ||
| 6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin. | ||
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