About 11 results found for searched term "MZ 1" (0.288 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1716 | Gemcitabine Hydrochloride | DNA/RNA Synthesis |
| Gemzar, LY-188011 | ||
| Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. | ||
| M9824 | MZ 1 | PROTAC |
| MZ1 | ||
| MZ 1 is a PROTAC BRD4 degrader, with Kd values of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively. | ||
| M50235 | MZ-101 | Others |
| MZ-101 is an orally active and selective inhibitor of small molecule glycogen synthase (GYS1) that reduces glycogen accumulation in skeletal muscle of a mouse model of Pompe disease. | ||
| M57015 | MZ-101 | Others |
| MZ-101 is a glycogen synthase 1 (GYS1) inhibitor. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M7822 | Gemfibrozil | PPAR |
| 吉非罗齐; CI-719 | ||
| Gemzil is a PPAR-α activator, which is a lipid-lowering agent. Gemfibrozil is also a nonselective inhibitor of P450, with Ki values of 5.8, 24,69 and 82 μM for CYP2C9, 2C19, 2C8 and 1A2, respectively. | ||
| M8189 | STF-62247 | Autophagy |
| STF62247; STF 62247 | ||
| Stf-62247 is an autophagy inducer with selective cytotoxicity against VHL-deficient renal cell carcinoma, with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. Stf-62247 can trigger ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M14652 | AMZ30 | Others |
| AMZ30 is a selective, covalent inhibitors of protein phosphatase methylesterase-1(PME-1; IC50=600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells. | ||
| M25109 | Lemzoparlimab | Others |
| TJ011133 TJC4 | ||
| Lemzoparlimab (TJ011133; TJC4) is a humanized anti-CD47 IgG4 antibody. Lemzoparlimab has a strong anti-tumor activity. | ||
| M40594 | Genolimzumab | PD-1/PD-L1 |
| Genolimzumab is a PD-1 monoclonal antibody that can be used in studies related to peripheral T-cell lymphoma (PTCL). | ||
| M57001 | Centhaquin | Others |
| Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. | ||
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