About 9 results found for searched term "ML 2-23" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1752 | Aliertib (MLN 8237) | Aurora Kinase |
| MLN-8237; MLN8237 | ||
| Alisertib (MLN8237) is a second-generation, orally bioavailable, highly selective Aurora kinase A inhibitor with IC50 of 61 nM. | ||
| M2285 | MLN2238 | Proteasome |
| Ixazomib | ||
| MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. | ||
| M9817 | MLS000532223 | Ras |
| MLS000532223 is a selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. | ||
| M43463 | ML 2-23 | PROTAC |
| ML 2-23 is a potent PROTAC BCR-ABL degrader. | ||
| M9700 | ML213 | Potassium Channel |
| CID-3111211 | ||
| ML213 (CID-3111211) is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener, with EC50 values of 230 and 510 nM for KV7.2 and KV7.4, respectively. | ||
| M9842 | ML228 | HIF |
| CID-46742353; ML 228 | ||
| ML228 is a potent the HIF pathway activator, with EC50 values of 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively. | ||
| M10689 | ML224 | TSH Receptor |
| NCGC00242364; ANTAG3 | ||
| ML224 (NCGC00242364; ANTAG3) is a thyroid-stimulating hormone receptor TSHR counter-agonist with an IC50 of 2.1uM. | ||
| M30806 | MLS1082 | Dopamine Receptor |
| MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling. | ||
| M40720 | I-138 | Deubiquitinase |
| I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. | ||
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