About 12 results found for searched term "Lenalidomide" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1962 | Lenalidomide | TNF Receptor |
| Revlimid, CC-5013 | ||
| Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. | ||
| M5732 | Lenalidomide hemihydrate | TNF Receptor |
| CC-5013 hemihydrate | ||
| Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM. | ||
| M43428 | Lenalidomide-acetylene-Br | PROTAC Linker |
| Lenalidomide-acetylene-Br is a PROTAC Linker taht makes up HJM-561. | ||
| M45283 | BTX161 | Casein Kinase |
| BTX161 is a Thalidomide analog and potent CKIα degrader.BTX161 mediates the degradation of CKIα better than Lenalidomide and activates the DNA damage response (DDR) and p53 while stabilizing the p53 antagonist MDM2 in human AML cells. | ||
| M6072 | Iberdomide | E1/E2/E3 Enzyme |
| CC220; CC 220; CC-220 | ||
| Iberdomide (CC-220) is an orally effective cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 for cereblon binding affinity of approximately 150 nM. Iberdomide (CC-220) binds CRBN with higher affinity than lenalidomide and pomalidomide and has enhanced degradation of IKZF1 and IKZF3 with enhanced degradation. | ||
| M14326 | Avadomide | E1/E2/E3 Enzyme |
| CC 122 | ||
| Avadomide (CC 122) is an orally effective cereblon modulator. avadomide modulates cereblon E3 ligase activity and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Avadomide has antitumor and immunomodulatory activities. CC-122 is more potent in degrading IKZF1 and IKZF3 than lenalidomide and has broader and enhanced antiproliferative activity in ABC- and GCB-DLBCL cell lines. | ||
| M14863 | CC-885 | Ligand for E3 Ligase |
| CC-885 is a regulator of CRBN protein with a wide range of strong CRBN-dependent anti-proliferative activity in various tumor cell lines, with enhanced anti-proliferative activity compared to lenalidomide and pomalidomide.CC-885 promotes the binding of CRBN to the novel substrate GSPT1, targeting its degradation. | ||
| M21159 | SD-36 | PROTAC |
| SD-36 is a potent STAT3 PROTAC degradation agent (Kd=~50 nM) with a high selectivity compared to other STAT members. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase. | ||
| M21406 | SI-109 | STAT |
| SI-109 is a potent STAT3 SH2 domain structural domain inhibitor (Ki=9 nM) with antitumor activity. si-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). si-109 and the CRBN analogue lenalidomide ligand were used to design the PROTAC STAT3 degradation agent SD- 36. | ||
| M21434 | INY-03-041 | PROTAC |
| INY-03-041 is an effective and highly selective Protac-based pan-Akt degradation consisting of GDC-0068, an ATP-competitive AKT inhibitor conjugated to lenalidomide (Cereblon ligand). INY-03-041 inhibited AKT1, AKT2 and AKT3 with IC50 values of 2.0 nM, 6.8 nM and 3.5 nM, respectively. | ||
| M29564 | SJF620 | PROTAC |
| SJF620 is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. | ||
| M31075 | SJF620 hydrochloride | PROTAC |
| SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. | ||
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