KRASG12C IN-2 - Search Results

About 4 results found for searched term "KRASG12C IN-2" (0.494 seconds)

Cat.No.	Name	Target
M41933	KRASG12C IN-2	Ras
	KRASG12C IN-2 is an orally active KRASG12C inhibitor.
M25612	Elironrasib	Ras
	RMC-6291
	Elironrasib is an orally active and covalent inhibitor of KRASG12C(ON). Elironrasib prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. Elironrasib inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. Elironrasib also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM.
M11427	RM-018	Ras
	INDEX NAME NOT YET ASSIGNED
	RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C.
M55031	BBO-8520	Ras
	BBO-8520 is a first-in-class orally active covalent KRAS G12C inhibitor. BBO-8520 inhibits KRASG12C (ON) by locking the GTP-binding protein in state 1, a conformation incapable of binding effectors, thereby inhibiting the downstream signaling of KRASG12C (ON) that promotes cell proliferation. BBO-8520 also rapidly and completely blocks the RAS-RAF1 interaction, returning KRASG12C to its inactive (OFF) state.