About 3 results found for searched term "KRASG12C IN-2" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41933 | KRASG12C IN-2 | Ras |
| KRASG12C IN-2 is an orally active KRASG12C inhibitor. | ||
| M11427 | RM-018 | Ras |
| INDEX NAME NOT YET ASSIGNED | ||
| RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C. | ||
| M55031 | BBO-8520 | Ras |
| BBO-8520 is a first-in-class orally active covalent KRAS G12C inhibitor. BBO-8520 inhibits KRASG12C (ON) by locking the GTP-binding protein in state 1, a conformation incapable of binding effectors, thereby inhibiting the downstream signaling of KRASG12C (ON) that promotes cell proliferation. BBO-8520 also rapidly and completely blocks the RAS-RAF1 interaction, returning KRASG12C to its inactive (OFF) state. | ||
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