About 12 results found for searched term "K11" (0.052 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1759 | GSK1120212 (Trametinib) | MEK |
| JTP-74057, GSK212 | ||
| Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis. | ||
| M2073 | Duvelisib (IPI-145) | PI3K |
| Duvelisib; INK1197 | ||
| Duvelisib (IPI-145) is a potent, oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma. | ||
| M6127 | TD-4208 | AChR/AChE |
| Revefenacin; GSK1160724 | ||
| Revefenacin (TD-4208; GSK1160724) is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity. | ||
| M8720 | PK11000 | p53 |
| PK11000 is a sulfhydryl active anticancer compound that stabilizes wild-type and mutated p53 through selective alkylation of two surface cysteines without interfering with their DNA binding. | ||
| M40975 | PK11007 | p53 |
| PK11007 is a mild thiol alkylating agent with anticancer activity that stabilizes p53 through selective alkylation of two surface-exposed cysteines without affecting its DNA-binding activity. It also induces death of mutant p53 cancer cells by increasing reactive oxygen species (ROS) levels. | ||
| M18496 | Kizuta saponin K11 | Others |
| Kizuta saponin K11 | ||
| M25157 | Ivonescimab | PD-1/PD-L1 |
| AK112 | ||
| Ivonescimab (AK112) is a PD-1/VEGF Bispecific Antibody. Ivonescimab can be used for cancer research. | ||
| M27746 | FKGK11 | Phospholipase |
| FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis. | ||
| M28268 | YK11 | Androgen Receptor |
| YK11 is a partial agonist of androgen receptor, with osteogenic activity. | ||
| M45211 | ABSK112 | EGFR/HER2 |
| ABSK112 is a potentially best-in-class, orally active, selective EGFR Exon20ins inhibitor with better brain entry properties, higher selectivity against wild-type EGFR, and broader Exon20ins mutation coverage profile. | ||
| M53543 | K11 | Antibiotic |
| K11 is an antimicrobial peptide. | ||
| M54457 | TLK117 | Others |
| TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. | ||
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