About 17 results found for searched term "IKK-IN-1" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14589 | IKK-IN-1 | IκB/IKK |
| IKK-IN-1 is an inhibitor of IKK. | ||
| M41237 | FIKK9.1-IN-1 | Parasite |
| FIKK9.1-IN-1 is a FIKK9.1 inhibitor. | ||
| M1801 | KU-55933 | ATM/ATR |
| KU55933 | ||
| KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR). | ||
| M2310 | BX-795 | PDK1 |
| BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively. | ||
| M2768 | IKK-16 | IκB/IKK |
| IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. | ||
| M4511 | Tectorigenin | Apoptosis |
| Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM. | ||
| M4574 | Wedelolactone | Caspase |
| Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11. | ||
| M6661 | Deguelin | Akt |
| (-)-Deguelin; (-)-cis-Deguelin | ||
| Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. | ||
| M9546 | TBK1/IKKε-IN-5 | IκB/IKK |
| ABM-7653; TBK1/IKK-epsilon-IN-5 | ||
| TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. | ||
| M14587 | TBK1/IKKε-IN-2 | IκB/IKK |
| TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor. | ||
| M14588 | IKK 16 hydrochloride | IκB/IKK |
| IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. | ||
| M14590 | MRT67307 | IκB/IKK |
| MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells. | ||
| M27830 | BOT-64 | IκB/IKK |
| BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription. | ||
| M28613 | BAY32-5915 | IκB/IKK |
| BAY32-5915 is a potent IKKα inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin-induced NF-κB activation. | ||
| M31066 | (Rac)-PF-184 hydrate | IκB/IKK |
| (Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects. | ||
| M31250 | HPN-01 | IκB/IKK |
| HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2. | ||
| M45049 | Ainsliadimer A | IκB/IKK |
| AIN | ||
| Ainsliadimer A is a novel guaiacolide sesquiterpene dimer isolated from Ainsliaea macrocephala.Ainsliadimer A can block the NF-κB signaling pathway by binding to IKK α/β, and possesses anti-tumor and anti-inflammatory activities.Meanwhile, Ainsliadimer A can also Ainsliadimer A can also directly target peroxidase 1 and 2 (PRDX1 and PRDX2) and significantly inhibit their enzymatic activities. In addition, Ainsliadimer A can cause mitochondrial dysfunction by altering the permeability of mitochondrial membrane potential, inhibiting mitochondrial respiration and ATP production, inhibiting cell proliferation, promoting cell cycle arrest in G2/M phase, and inducing apoptosis. | ||
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