About 4 results found for searched term "HPK1-IN-2" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21037 | HPK1-IN-2 | Serine/Threonine Protease |
| HPK1-IN-2 is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1, a serine/threonine Ste20-related protein kinase), Lck and Flt3 with IC50 of <0.05 μM, IC50 of <0.5 μM and IC50 of <0.05 μM, respectively. HPK1-IN-2 exhibits antitumor activity. | ||
| M10831 | HPK1-IN-3 | MAPKAPK2/MAP3K/MAP4K |
| HPK1-IN-3 is a potent selective ATP competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor,IC50 0.25 nM. HPK1-IN-3 has IL-2 cell potency, EC in human peripheral blood mononuclear cells (PBMCs).50 108 nM. | ||
| M10832 | HPK1-IN-7 | MAPKAPK2/MAP3K/MAP4K |
| HPK1-IN-7 is a potent inhibitor of the orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) (IC50=2.6 nM), with excellent family and kinase group selectivity. The HPK1-IN-7 is selective for IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 combined with anti-PD1 has shown powerful efficacy in MC38 cogenic tumor models. | ||
| M42138 | HPK1-IN-39 | MAPKAPK2/MAP3K/MAP4K |
| HPK1-IN-39 is a selective HPK1 Inhibitor (IC50: 29 nM). | ||
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