About 11 results found for searched term "Exatecan" (0.11 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9101 | Exatecan mesylate | Topoisomerase |
| DX-8951f | ||
| Exatecan Mesylate (DX8951f) is a water soluble DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). | ||
| M10402 | MC-GGFG-DX8951 | Drug-Linker Conjugates for ADC |
| Trastuzumab Impurity 1; MC-GGFG-Exatecan | ||
| MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker. | ||
| M13744 | Dxd | Topoisomerase |
| Exatecan derivative for ADC | ||
| Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). | ||
| M41008 | Val-Ala-PABC-Exatecan | Drug-Linker Conjugates for ADC |
| Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor). | ||
| M41011 | NH2-methylpropanamide-Exatecan TFA | Topoisomerase |
| NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan, which is the common ADC Cytotoxin used in the synthesis of ADC. | ||
| M41611 | Exatecan mesylate dihydrate | Topoisomerase |
| Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. | ||
| M42945 | Decyclohexanamine-Exatecan | Others |
| Decyclohexanamine-Exatecan is a Camptothecin derivative, compound a, extracted from patent WO2020219287 A1. | ||
| M55706 | (4-NH2)-Exatecan | Others |
| (4-NH2)-Exatecan, a topoisomerase inhibitor, is a derivative of Exatecan. | ||
| M55703 | Exatecan Intermediate 6 | Others |
| Exatecan Intermediate 6 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. | ||
| M59402 | MC-VA-PAB-Exatecan | Drug-Linker Conjugates for ADC |
| MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. | ||
| M66155 | Exatecan | Topoisomerase |
| DX-8951 | ||
| Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM. Exatecan significantly inhibits the proliferation of several cancer cell lines, with mean GI50s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. | ||
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