About 33 results found for searched term "Eact" (0.072 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6695 | Eact | Chloride Channel |
| Eact is a activator of Ca 2+-activated Cl - channel transmembrane protein 16A (TMEM16A). | ||
| M51617 | C-Reactive Protein (CRP) (77-82) | Others |
| C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of C-Reactive Protein. | ||
| M51626 | C-Reactive Protein (CRP) (201-206) | Others |
| C-Reactive Protein (CRP) 201-206 is the 201-206 fragment of C-Reactive Protein. | ||
| M53960 | C-Reactive Protein (CRP) (174-185) | Others |
| C-Reactive Protein (CRP) 174-185 is the 174-185 fragment of C-Reactive Protein. | ||
| M1992 | 2-Methoxyestradiol | HIF |
| 2ME2 | ||
| 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa. | ||
| M2598 | Inauhzin | p53 |
| INZ | ||
| Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell). | ||
| M2755 | Histamine Phosphate | Histamine Receptor |
| Histamine diphosphate | ||
| Histamine Phosphate is an endogenous ligand for the histamine receptor that can induce allergic reactions by acting with H1 receptors, promote acid secretion by acting with H2 receptors, and inhibit histamine release and modulate immune responses by acting with H3 receptors and H4 receptors. It can be used in studies related to allergy, hyperacidity, sleep disorders, asthma and many other diseases. | ||
| M2756 | Histamine dihydrochloride | Histamine Receptor |
| Histamine 2HCl is an endogenous ligand for the histamine receptor, which can cause allergic reactions by interacting with H1 receptors, promote acid secretion by interacting with H2 receptors, as well as inhibit histamine release and modulate immune responses by interacting with H3 receptors and H4 receptors. It can be used in studies related to allergy, hyperacidity, sleep disorders, asthma and many other diseases. | ||
| M3187 | Optovin | TRP Channel |
| Optovin is a reversible photoactivated TRPA1 activator. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. | ||
| M3837 | β-Glycerophosphate disodium salt hydrate | Phosphatase |
| BGP; CAS# 154804-51-0 | ||
| β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. | ||
| M3847 | Alemtuzumab | Others |
| Campath-1H | ||
| Alemtuzumab is a recombinant DNA-derived humanized IgG1 kappa monoclonal antibody that is directed against the 21-28 kDa cell surface glycoprotein CD52. Alemtuzumab does not cross-react with mouse CD52, making in vivo studies in wild-type mice unfeasible. | ||
| M1498 | Methylmalonic acid | Others |
| Methylmalonic acid can be used as a substrate in esterification reactions by various catalysts. | ||
| M4058 | 11-oxo-mogroside-V | ROS |
| 11-Oxo-Mogroside V is a natural sweetener with strong antioxidant activity. 11-OXo-Mogroside V had a significant inhibitory effect on reactive oxygen species, and the EC50 of O2-, H2O2 and *OH were 4.79, 16.52 and 146.17 μg/mL, respectively. | ||
| M4110 | 23-Acetyl-alisol-C | Others |
| 23-O-Acetylalisol C; Alisol C monoacetate | ||
| Alisol C 23-acetate is a natural product extracted from Alisol orientalis, which can significantly reduce delayed hypersensitivity reaction. | ||
| M4146 | Sodium-Danshensu | Cytochrome P450 (e.g. CYP17) |
| Sodium Danshensu; (±)-DanShenSu sodium sal | ||
| Danshensu (sodium) is the active component of salvia miltiorrhiza, which can inhibit the formation of reactive oxygen species, inhibit platelet adhesion and aggregation, and protect myocardial ischemia. | ||
| M4249 | Schisandrol B | NF-κB |
| Gomisin-A; Besigomsin; schizandrol-B; TJN-101; Wuweizi alcohol-B; Wuweizichun-B | ||
| Schisandrol B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities. | ||
| M4552 | Nobiletin | Autophagy |
| Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes. | ||
| M4559 | Ziyuglycoside-II | Apoptosis |
| Ziyuglycoside II from Sanguisorba officinalis L. Triterpenoid saponins extracted from the. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. It has anti-inflammatory and anticancer effects. | ||
| M4896 | Nicotinamide | Sirtuin |
| Vitamin B3; Nicotinic acid amide; Niacinamide | ||
| Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. | ||
| M5059 | Furafylline | Cytochrome P450 (e.g. CYP17) |
| Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM. | ||
| M5243 | EED226 | PRC2/EED |
| EED226 is an effective, selective and orally active Polycomb reactive complex 2 (PRC2) inhibitor. When h3k27me0 peptide is used as substrate, ic50=23.4 nm; With mononucleosome as substrate, ic50=53.5 nm. It is a first in class, effective, orally bioavailable inhibitor of embryonic ectodermal development (EED) with strong anticancer effect. | ||
| M5251 | MCB-613 | ROS |
| MCB613 | ||
| MCB-613 is a potent steroid receptor coactivator (SRC) stimulator. MCB-613 increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). | ||
| M5286 | Acrivastine | EGFR/HER2 |
| BW825C | ||
| Acrivastine is a novel antihistamine compound whose peripheral Hi-antagonist has the same potency as trichloropyridine, but doses of up to 4mg of atorvastatin do not reduce alert performance or increase response time. reaction time. | ||
| M5692 | Histamine | Histamine Receptor |
| Ergamine | ||
| Histamine is an endogenous ligand for histamine receptors, which can cause allergic reactions by interacting with H1 receptors, promote acid secretion by interacting with H2 receptors, as well as inhibit histamine release and modulate immune responses by interacting with H3 receptors and H4 receptors. It can be used in studies related to allergy, hyperacidity, sleep disorders, asthma and many other diseases. | ||
| M11217 | Methyl α-D-glucopyranoside | Solvents & Excipients |
| Methyl α-D-glucoside | ||
| Methyl α-D-glucopyranoside can be used in a study to investigate saccharide-mediated protection of chaotropic-induced deactivation of concanavalin A. | ||
| M5753 | L-Ornithine | Metabolite/Endogenous Metabolite |
| (S)-2,5-Diaminopentanoic acid | ||
| L-ornithine has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle. | ||
| M5792 | Mizolastine | Histamine Receptor |
| SL 850324 | ||
| Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. | ||
| M5890 | Pralidoxime chloride | AChR/AChE |
| 2-PAM (chloride) | ||
| Pralidoxime is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator. | ||
| M6101 | Atezolizumab | PD-1/PD-L1 |
| MPDL3280A,Anti-PD-L1；Tecentriq | ||
| Atezolizumab (atezolizumab) is a humanized anti-PD-L1 monoclonal antibody that inhibits PD-L1 signaling with PD-1 and B7-1 and restores tumor-specific T-cell immunity. However, it does not affect the interaction of PD-L2 with PD-1. MW: 145 KD. atezolizumab reacts with murine PD-L1 (for human and non-humanized mice). | ||
| M6214 | 6-Maleimidocaproic Acid | PROTAC Linker |
| A sulfhydryl reactive heterobifunctional crosslinking reagent. Widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins. | ||
| M6561 | Carboxy-PTIO, potassium salt | NO Synthase |
| Carboxy-PTIO, potassium salt is a stable, water-soluble deactivator of NO. | ||
| M6903 | Leptomycin B | Antibiotic |
| CI 940; LMB | ||
| Leptomycin B (CI 940; LMB (LMB) is a protein exit nuclear transport inhibitor. Leptomycin deactivates CRM1/exportin 1 by covalent modification at cysteine residues. Leptomycin B is a potent antifungal antibiotic that blocks the eukaryotic cell cycle. | ||
| M8072 | PF-06672131 | Others |
| PF-06672131 is a selective EGFR kinase inhibitor thought to covalently react with active-site cysteine residues in the ATP binding pocket. | ||
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