About 20 results found for searched term "E3 ligase Ligand 2" (0.238 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9832 | E3 ligase Ligand 2 | Ligand for E3 Ligase |
| Thalidomide-4-OH; Cereblon ligand 2 | ||
| E3 ligase Ligand 2 (Thalidomide-4-OH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can be connected to the ligand for protein by a linker to form PROTACs. | ||
| M14861 | Thalidomide-O-amido-C8-NH2 TFA | PROTAC |
| Cereblon Ligand -Linker Conjugates 2 TFA; E3 Ligase Ligand-Linker Conjugates 20 TFA | ||
| Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||
| M9826 | E3 ligase Ligand 1 | Ligand for E3 Ligase |
| VHL ligand 2 hydrochloride; (S,R,S)-AHPC-Me hydrochloride | ||
| E3 ligase Ligand 1 (VHL ligand 2 hydrochloride; (S,R,S)-AHPC-Me hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. | ||
| M22449 | Pomalidomide-PEG2-COOH | PROTAC |
| Pomalidomide 4'-PEG2-acid | ||
| Pomalidomide-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. | ||
| M29577 | PROTAC Bcl2 degrader-1 | PROTAC |
| PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. | ||
| M29585 | KB02-SLF | PROTAC |
| KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF. | ||
| M29586 | KB02-JQ1 | PROTAC |
| KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1. | ||
| M43417 | AR antagonist 1 hydrochloride | Ligand for E3 Ligase |
| AR antagonist 1 hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. | ||
| M54696 | DGY-09-192 | PROTAC |
| DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells. | ||
| M57108 | (S,R,S)-AHPC-C3-NH2 | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. | ||
| M57107 | (S,R,S)-AHPC-C8-NH2 | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. | ||
| M57106 | (S,R,S)-AHPC-C7-amine | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader. | ||
| M57105 | VH032-PEG3-acetylene | E3 Ligase Ligand-Linker Conjugates |
| VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. | ||
| M57104 | (S,R,S)-AHPC-C3-NH2 TFA | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. | ||
| M57100 | (S,R,S)-AHPC-C3-NH2 hydrochloride | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. | ||
| M57097 | (S,R,S)-AHPC-C8-NH2 hydrochloride | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. | ||
| M57090 | (S,R,S)-AHPC-C7-amine hydrochloride | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C7-amine (VH032-C7-amine) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader. | ||
| M57089 | (S,R,S)-AHPC-C8-NH2 dihydrochloride | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. | ||
| M57085 | (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride | E3 Ligase Ligand-Linker Conjugates |
| (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and an alkyl linker used for PROTAC degrader. | ||
| M59090 | ML 2-14 | PROTAC |
| ML2-14 | ||
| ML 2-14 is a E3-recruiting (RNF114, RNF4)-based PROTAC. ML 2-14 is targeting BRD4 with a C4 alkyl linker. ML 2-14 consists of the E3 ligase ligand EN219, the target protein ligand JQ-1, and the PROTAC linker. ML 2-14 can effectively degrade BRD4 in 231MFP breast cancer cells. | ||
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