About 31 results found for searched term "DIF-3" (0.082 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7742 | DIF-3 | GSK-3 |
| DIF3 | ||
| DIF-3 inhibits cell cycle by inducing G0/G1 arrest. DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. | ||
| M57745 | 6-bromo-2-(difluoromethyl)-3-fluoropyridine | Others |
| 6-bromo-2-(difluoromethyl)-3-fluoropyridine | ||
| M25448 | Dehydrolithocholic acid | ROR |
| 3-Oxo-5β-cholanoic acid | ||
| Dehydrolithocholic acid is a bile acid metabolite, which inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM). | ||
| M2198 | Curcumin | Histone Acetyltransferase |
| Indian Saffron; Turmeric yellow; Natural Yellow 3; Diferuloylmethane | ||
| Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. | ||
| M2985 | Rolitetracycline | Antibiotic |
| Rolitetracycline is a tetracycline antibiotic, which passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis. | ||
| M4083 | Ginsenoside-F1 | Cytochrome P450 (e.g. CYP17) |
| 20(S)-Ginsenoside F1 | ||
| Ginsenoside F1 is an enzymatically modified derivative of Ginsenoside Rg1. Ginsenoside F1 competently inhibits CYP3A4 and has a weak inhibitory effect on CYP2D6. | ||
| M4680 | Rubimaillin | NF-κB |
| Mollugin is Rubia Cordifolia L. Is a major bioactive ingredient in the. Mollugin has anticancer effects by inhibiting NF-κB activation induced by TNF-α. Mollugin can enhance the osteogenic effect of BMP-2 through the P38-Smad signaling pathway. | ||
| M4705 | Asperosaponin-VI | Caspase |
| Akebia saponin D | ||
| Asperosaponin-VI induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. | ||
| M5105 | MD2-TLR4-IN-1 | TLR |
| MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. | ||
| M6602 | Ciglitazone | PPAR |
| ADD-3878; U-63287 | ||
| Ciglitazone is an effective selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibited the proliferation and differentiation of TH17 cells. Ciglitazone is an oral hypoglycemic agent that has been shown to be active in obese hyperglycemic animal models. Ciglitazone induces apoptosis in opossum renal epithelial cells and simultaneously activates nuclear translocation of P38 MAPK and apoptosis-inducing factor (AIF). | ||
| M50170 | ARV-393 | PROTAC |
| ARV-393 is an orally active PROTAC degrader targeting BCL6 for studies related to diffuse large B-cell lymphoma. ARV-393 utilizes the ubiquitin-proteasome system to target the degradation of BCL6. | ||
| M8767 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. | ||
| M8783 | Lys05 | Autophagy |
| Lys01 trihydrochloride | ||
| Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15. | ||
| M9044 | MIK665 | Bcl-2 |
| S-64315 | ||
| MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3). | ||
| M9289 | E6446 dihydrochloride | TLR |
| E6446 2HCl; E-6446 hydrochloride | ||
| E6446 dihydrochloride is a potent and orally acitve antagonist of TLR7 and TLR9. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. | ||
| M10044 | Albiglutide | GLP Receptor |
| Albiglutide is a recombinant fusion protein consisting of two copies of a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36), modified with a glycine substituted for the naturally occurring alanine at position 8 in order to augment resistance to DPP-4. | ||
| M10183 | Difopein TFA | Peptides |
| Difopein TFA is a specific and competitive inhibitor of 14-3-3 protein, blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. | ||
| M10491 | Batabulin sodium | Microtubule |
| T138067 sodium | ||
| Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis. | ||
| M10645 | MS402 | Epigenetic Reader Domain |
| MS-402 | ||
| MS402 is a novel BD1-selective BET BrD inhibitor, inhibiting primarily Th17 cell differentiation with a little or almost no effect on Th1 or Th2 and Treg cells. MS402 has Ki values of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. | ||
| M10924 | LY-3475070 | Immunology/Inflammation |
| Ly-3475070 is the first oral bioavailable, selective and extracellular enzyme CD73 (cluster of Differentiation 73, 5'-ecto-nucleotidase, 5' -nt, Ecto -5'-nucleotidase) inhibitor. | ||
| M11215 | Fibrinogen (Bovine) | Others |
| Fibrinogen (Fg), i. e. coagulation factor I, molecular weight about 340kDa, by α, β, γ three pairs of different polypeptide chain. Polypeptide chains are linked by disulfide bonds. Protein Content: 67.30. | ||
| M11308 | E6446 | TLR |
| E-6446 | ||
| E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. | ||
| M11495 | Recombinant Human TNF-α (E. coli) | Cytokines and Growth Factors |
| TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin | ||
| Recombinant human TNF-α protein (E. coli) is a homotrimer with a subunit molecular mass of 17.3 kDa. TNF-a plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases; and in viral, bacterial, fungal, and parasitic infections. ED50 < 30.0 pg/ml, measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D, corresponding to a specific activity of > 3.3 × 107 units/mg. | ||
| M13380 | Tapotoclax | Bcl-2 |
| AMG-176；CS-2836 | ||
| Tapotoclax is an inhibitor of myeloid leukemia cell differentiation protein McL-1 (myeloid leukemia-1) with a Ki value of 0.13 nM and has potential pro-apoptotic and anti-tumor activity. | ||
| M13563 | AC-73 | Autophagy |
| AC73 | ||
| AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. | ||
| M14326 | Avadomide | E1/E2/E3 Enzyme |
| CC 122 | ||
| Avadomide (CC 122) is an orally effective cereblon modulator. avadomide modulates cereblon E3 ligase activity and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Avadomide has antitumor and immunomodulatory activities. CC-122 is more potent in degrading IKZF1 and IKZF3 than lenalidomide and has broader and enhanced antiproliferative activity in ABC- and GCB-DLBCL cell lines. | ||
| M14488 | DIPQUO | Phosphatase |
| DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β. | ||
| M17278 | Broussonin B | Phenols |
| Broussonin B is a phenolic compound isolated from the stem barks of Broussonetia kanzinoki (Moraceae). Broussonin B inhibits adipocyte differentiation in 3T3-L1 cells. | ||
| M17572 | Tagitinin A | Sesquiterpenoids |
| Tagitinin A is a sesquiterpene with anti-hyperglycemic activity. Tagitinin A significantly inhibits glucose uptake in differentiated 3T3-L1 adipocytes. | ||
| M20000 | APCP | Others |
| AMP-CP；ADP[α，β-CH2]；methadp | ||
| APCP (adenosine 5 '- (α, β-methylene) diphosphate) is a specific CD73 inhibitor. To investigate its inhibitory effect on CD73 or regulation of extracellular -5 '-nucleotidase mediated differentiation cluster 73(CD73) and adenylinergic signaling. | ||
| M20779 | Brequinar Sodium | DHODH |
| Bipenquinate, BRQ, DUP-785, NSC 368390 | ||
| Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM. | ||
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