About 12 results found for searched term "D-4-77" (0.071 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2700 | FH1 | Others |
| NSC 12407; BRD-K4477 | ||
| FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes. FH1 (NSC 12407) enhances hepatocyte functions, and promotes the differentiation of induced pluripotent stem (iPS)-derived hepatocytes toward a phenotype more mature and the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps). | ||
| M3672 | AZD4877 | Kinesin |
| AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. | ||
| M5952 | Saxagliptin hydrate | Dipeptidyl Peptidase |
| BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate | ||
| Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. | ||
| M8083 | MCC950 sodium salt (CP-456773) | Pyroptosis |
| CP-456773 sodium; CRID3 sodium salt | ||
| MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. | ||
| M8397 | BRD4770 | Histone Methyltransferase |
| BRD4770 is a histone methyltransferase G9a inhibitor. BRD4770 inhibited the dimethylation and trimethylation of H3K9, EC50 was 5 µM, and had little effect on H3K27me3, H3K36me3, H3K4me3, and H3K79me3. BRD4770 activates the ataxic telangiectasia mutation (ATM) pathway and induces cell senescence. | ||
| M13588 | Methotrexate disodium | Antifolate |
| Amethopterin disodium; CL14377 disodium; WR19039 disodium | ||
| Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. | ||
| M14126 | Avatrombopag hydrochloride | Thrombopoietin/Thrombin |
| AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride | ||
| Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. | ||
| M24584 | Volagidemab | Others |
| REMD-477; AMG-477 | ||
| Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D). | ||
| M25030 | Daxdilimab | Anti-infection |
| MEDI7734; VIB7734 | ||
| Daxdilimab is an anti-ILT7 monoclonal antibody, ILT7 is a cell surface molecule specific to the pDC type of dendritic cells. Daxdilimab can be used in acute lung injury (ALI) in patients with COVID-19 infection research. | ||
| M41268 | D-4-77 | Anti-infection |
| D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 0.95 μM. | ||
| M49909 | ML230 | BCRP/ABCG2/MXR/ABCP |
| CID44640177; SID 88095709 | ||
| ML230 is a selective inhibitor of the ATP-binding transporter subtype ABCG2, and its inhibitory effect on ABCG2 was 36 times that of ABCB1, with EC50 values of 0.13 μM and 4.65 μM, respectively. | ||
| M55997 | AZD4877 | Kinesin |
| AZD4877 is another isostere to Ispinesiband also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. | ||
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