About 30 results found for searched term "Cathepsin K" (0.139 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21451 | Recombinant Human Cathepsin K protein (E.coli) | Cytokines and Growth Factors |
| CTSK；Cathepsin K；Cathepsin O；Cathepsin O2 | ||
| Protein construction: The DNA sequence encoding human CTSK (Ala115-Met329) is fused with His tag. Accession #P43235. | ||
| M50355 | Cathepsin K | Enzymes & Coenzymes |
| Cathepsin K is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M52662 | Cathepsin K inhibitor 5 | Cathepsin |
| Cathepsin K inhibitor 5 is a potent Cathepsin K inhibitor. | ||
| M1985 | Odanacatib | Cathepsin |
| MK-0822 | ||
| Odanacatib (MK-0822) is a potent and reversible covalent inhibitor of CathepsinK (CatK) with an IC50 of 0.2 nM/1 nM for human/rabbit cathepsin B, L, and S and is highly selective. | ||
| M1987 | LY2886721 | BACE |
| LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease. | ||
| M2600 | Balicatib | Cathepsin |
| AAE-581 | ||
| Balicatib is a potent and selective inhibitor of cathepsin K; 10-100-fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. | ||
| M2497 | Cathepsin Inhibitor 1 | Cathepsin |
| Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. | ||
| M3636 | Leupeptin hemisulfate | Cathepsin |
| Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin. | ||
| M5221 | MG-101 | Proteasome |
| Calpain inhibitor I; Ac-LLnL-CHO; ALLN | ||
| MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). IC50 value: 150 nM (Ki) | ||
| M6237 | CA-074 | Caspase |
| CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM. | ||
| M10280 | L006235 | Cathepsin |
| L235; L-006235; L-235 | ||
| L006235 (L235) is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. | ||
| M10412 | Val-cit-PAB-OH | ADC Linker |
| Val-cit-PAB-OH is a cathepsin cleavable ADC peptide linker for making MC-Val-Cit-PAB, which is also known as MC-Val-Cit-PAB-OH. | ||
| M13538 | Z-WEHD-FMK | Caspase |
| Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis. | ||
| M14304 | 3-Epiursolic Acid | Cathepsin |
| 3-Epiursolic Acid is a triterpenoid isolated from Myrtaceae, acts as a competitive inhibitor of cathepsin L (ICIC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B. | ||
| M20881 | 2-cyano-Pyrimidine | Others |
| 2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM. | ||
| M27825 | KGP94 | Cathepsin |
| KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines. | ||
| M28225 | MIV-247 | Cathepsin |
| MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively. | ||
| M28912 | (Rac)-Calpain Inhibitor XII | Proteasome |
| (Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). | ||
| M29515 | K777 | Cathepsin |
| K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively. | ||
| M29991 | Relacatib | Cathepsin |
| SB-462795 | ||
| Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC50 values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo. | ||
| M30349 | L-873724 | Cathepsin |
| L-873724 is a potent, orally bioavailable, selective and reversible[2] non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption. | ||
| M30755 | ONO-5334 | Cathepsin |
| ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease. | ||
| M41002 | AcLys-PABC-VC-Aur0101 intermediate-1 | ADC Linker |
| AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. | ||
| M42301 | JNJ 10329670 | Cathepsin |
| JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. | ||
| M42905 | Cathepsin Inhibitor 3 | Others |
| Cathepsin Inhibitor 3 is a non-radioactive intermediate in compound [18F] 2k radioactive synthesis, which has selectivity for cathepsin S. | ||
| M43194 | Cathepsin B | Enzymes & Coenzymes |
| Cathepsin B is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death). | ||
| M43254 | Abz-HPGGPQ-EDDnp | Others |
| Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. | ||
| M54370 | Z-Gly-Pro-Arg-AMC hydrochloride | Cathepsin |
| Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. | ||
| M55722 | Phe-Lys(Trt)-PAB | ADC Linker |
| Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs). | ||
| M58628 | Recombinant Mouse Progranulin Protein (HEK293, C-His) | Other Proteins |
| PGRN | ||
| Progranulin (PGRN) proteins regulate lysosomal function, affecting protein transport, enzymatic activity, and acidification. It degrades mature cathepsin D via cathepsin B. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. | ||
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