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Recombinant Human Cathepsin K protein (E.coli)

Cat. No. M21451

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human Cathepsin K protein (E.coli) Structure
Synonym:

CTSK;Cathepsin K;Cathepsin O;Cathepsin O2

Size Price Availability Quantity
50ug USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

Species: Human
Expression system: E.coli
Purity: > 90% as determined by SDS-PAGE
Predicted molecular weight: 25.81 kDa
Storage and stability: Use manual defrosting freezers to avoid repeated freeze-thaw cycles. Store at 2-8 °C for one week. Store at -20 to -80°C for 12 months from the date of receipt.



Biological activity: Mercaptan protease is involved in bone resorption in osteoclasts and may be partially involved in bone remodeling disorders. Showed strong protease activity against fibrinogen at acidic ph. It may play an important role in the degradation of extracellular matrix. Involved in the release of the thyroid hormone thyroxine (T4) through limited TG/ thyroglobulin proteolysis in the thyroid follicular lumen

Chemical Information
Solubility (25°C) Reconstitute in sterile water for a stock solution.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dongzheng Gai, et al. J Clin Invest. CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation

[2] Huaqiang Tao, et al. Pharmacol Res. Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways

[3] Rui Li, et al. Cell Death Differ. Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

[4] Jennifer A Bennett, et al. Am J Surg Pathol. Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors

[5] F Bhling, et al. Adv Exp Med Biol. Cathepsin K expression in human lung

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Keywords: Recombinant Human Cathepsin K protein (E.coli), CTSK;Cathepsin K;Cathepsin O;Cathepsin O2 supplier, Cytokines and Growth Factors, inhibitors, activators

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