About 34 results found for searched term "CY3-SE" (0.068 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10195 | MOG (35-55) (Mouse, rat) | Animal Modeling |
| Myelin Oligodendrocyte Glycoprotein (35-55) (Mouse, rat) | ||
| MOG (35-55) (Mouse, rat) is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. | ||
| M14818 | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | Peptides |
| MOG (35-55) (TFA) | ||
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA) is a minor component of CNS myelin. | ||
| M31321 | CY3-SE | Fluorescent Dye |
| CY3 NHS ESTER | ||
| CY3-SE (CY3 NHS ESTER) is a near-infrared fluorescent labeling dye that can be used to label biomolecules such as peptides, proteins and oligomers. | ||
| M54197 | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat | Animal Modeling |
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. | ||
| M1800 | JNJ-7706621 | CDK |
| JNJ7706621 | ||
| JNJ-7706621 is a dual cell cycle inhibitor with activity against cyclin-dependent kinases (CDK1, 2, 3, 6) with an IC50 of 3-175 nM and Aurora kinases (A and B) with an IC50 of 11-15 nM respectively. | ||
| M2281 | Exemestane | Others |
| Aromasin | ||
| Exemestane, a kind of Aromatase (CYP19A1) inhibitor, more profoundly inhibited the cell proliferation of KKU-213 cells highly expressing CYP19A1, and inhibited Aromatase in human placenta and rat ovary, with IC50 of 30 nM and 40 nM, respectively. | ||
| M25536 | Recombinant Human CXCL13/BCA-1 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | ||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | ||
| M2929 | PF-4981517 | Cytochrome P450 (e.g. CYP17) |
| CYP3cide, PF-04981517 | ||
| PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. | ||
| M3381 | Nevirapine | Reverse Transcriptase |
| BI-RG 587; NSC 641530; NVP | ||
| Nevirapine (NSC 641530) is a potent, specific non-nucleoside reverse transcriptase inhibitor (NNRTIs) that non-competitively inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with a Ki of 220 nM. Nevirapine (NSC 641530) can be used in AIDS-related researchs. | ||
| M3425 | Mitotane | Apoptosis |
| 2,4′-DDD; o,p'-DDD | ||
| Mitotane is an isomer of DDD and a derivative of DDT that induces CYP3A4 gene expression through steroid and exogenous receptor (SXR) activation, and has anticancer activity, and may be used in studies related to adrenocortical carcinoma. | ||
| M3636 | Leupeptin hemisulfate | Cathepsin |
| Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin. | ||
| M3827 | CY7 | Fluorescent Dye |
| Sulfo-Cyanine7 carboxylic acid | ||
| Cy7 (Sulfo-Cyanine7) is a fluorescence labeling agent (Ex=750 nm, Em=773 nm), used to label proteins, antibodies, peptides, and oligonucleotides. | ||
| M11227 | FM-479 | JAK |
| Fm-479 was a negative control of FM-381 and showed no activity against JAK3 or other kinases. Fm-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909. For JAK3, FM-381 was 410, 2700 and 3600 times more selective than JAK1, JAK2 and TYK2 with IC50 of 127 pM. | ||
| M4306 | Ganoderic-acid-D | Sirtuin |
| Ganoderic acid D is a highly oxidized tetracyclic triterpenoid that is the main active ingredient in Ganoderma lucidum. Ganoderic acid D upregulates protein expression for SIRT3 and induces deacetylated cyclophilic protein D (CypD) through SIRT3. Ganoderic acid D inhibits energy reprogramming in colon cancer cells, including glucose uptake, lactate production, pyruvate, and acetyl-Coenzyme production in colon cancer cells. | ||
| M4805 | BIBX 1382 | EGFR/HER2 |
| Falnidamol | ||
| BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). | ||
| M5062 | Polyinosinic:polycytidylic acid | TLR |
| poly I:C; Poly (I:C) | ||
| Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. | ||
| M5233 | Osilodrostat | Mineralocorticoid Receptor |
| LCI699 | ||
| Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. | ||
| M5259 | Citarinostat | HDAC |
| ACY-241 | ||
| Citarinostat (ACY-241) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3. | ||
| M5519 | Cilostazol | Animal Modeling |
| OPC-13013 | ||
| Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. It can be used to construct animal models of deep vein thrombosis. | ||
| M5719 | Itraconazole | Antibiotic |
| R 51211 | ||
| Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. | ||
| M5827 | Oclacitinib maleate | JAK |
| PF-03394197 | ||
| Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases. | ||
| M11359 | Recombinant Human IL-6R (CHO) | Cytokines and Growth Factors |
| IL-6RA; IL-6R1; CD126; IL-6RA | ||
| Interleukin-6 Receptor Alpha belongs to the type I cytokine receptor family. It binds specifically to IL-6 and depends on gp130 to transmit signals. Measured in a cell proliferation assay using M1 cells in the presence of 10.0 ng/ mL human IL-6, the ED50 is < 0.2 μg/mL. | ||
| M6132 | ECBN HCL | Others |
| ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase. | ||
| M6291 | 5-Iodotubercidin | PKA |
| NSC 113939, 5-ITu | ||
| 5-IOdotubercidin (NSC 113939), an ATP analogue, is a potent inhibitor of adenosine kinase with an IC50 value of 26 nM. 5-IOdotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by activating phosphorylase and glycogen synthase. 5-IOdotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin inhibitors. | ||
| M6447 | Apcin | APC |
| Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin is a cdc20 inhibitor; inhibits Cdc20-substrate interaction. | ||
| M6589 | CGP 60474 | CDK |
| CGP60474 is a highly effective anti-endotoxin compound, It is an effective cyclin-dependent kinase (CDK) inhibitor (IC50 of CDK1/B, CDK2/E, CDK2/ A, CDK4/D, CDK5/ P25, CDK7/H and CDK9/T are 26, 3, 4, 216, 10, 200 and 13 nM, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor. | ||
| M6853 | JW 642 | MAGL |
| Jw642 is a highly effective selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6 nM, 14 nM and 3.7 nM in mouse, rat and human meninges, respectively. | ||
| M7123 | PF 5006739 | Casein Kinase |
| PF 5006739 is a potent, selective CK1δ/ε inhibitor with IC50s of 3.9 nM and 17.0 nM, respectively, and possesses low nanomolar CK1δ/ε potency in vitro and high kinome selectivity. In addition, PF-5006739 improves glucose tolerance in diet-induced obesity (DIO) and genetic (ob/ob) mouse models. It can be used in studies of psychiatric disorders. | ||
| M7327 | Lintitript | Cholecystokinin Receptor |
| SR 27897 | ||
| Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). | ||
| M7775 | 3-Deazaadenosine | Anti-infection |
| 3-DZA | ||
| 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells. | ||
| M8202 | Sandoz 58-035 | Transferase |
| Sandoz 58-035 is a cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture. Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages. | ||
| M8431 | CYM50358 | S1P Receptor |
| CYM50358 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). | ||
| M8488 | Ophiopogonin D' | Sirtuin |
| Ophiopogonin D', isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines mG-63 and SNU387. Ophiopogonin D' can induce necrotic apoptosis of prostate cancer LNCaP cells by activating RIPK1. IC50 were 3.09 μM and 3.63 μM, respectively. SIRT1 is activated in a dose-dependent manner by Ophiopogonin D'. | ||
| M8747 | Synta66 | Calcium Channel |
| Synta66 (S66) is a CRAC (Ca2+ release-activated Ca2+) channel inhibitor that blocks SOCE (store-operated Ca2+ entry) upon Ca2+ depletion from intracellular stores by thapsigargin in human vascular smooth muscle cells (VSMCs) with high potency (IC50 = 26 nM & 43 nM based on maximum Ca2+ level & rate of increase, respectly). | ||
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