About 9 results found for searched term "AZ-67" (0.057 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1732 | Talazoparib (BMN-673) | PARP |
| BMN673; LT-673 | ||
| Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. | ||
| M1897 | AZD6765 | GluR |
| AZD6765 is an NMDA receptor antagonist. | ||
| M4854 | BMN-673 8R,9S | PARP |
| Talazoparib (8R,9S); (8R,9S)-LT-673 | ||
| BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. | ||
| M8914 | Ceralasertib (AZD6738) | ATM/ATR |
| Ceralasertib (AZD6738) is an orally active, selective ATR kinase inhibitor with an IC50 of 1 nM. AZD6738 inhibits ATR kinase activity and impels cell viability. AZD6738 induces rapid cell death in tumor cells with an ATM gene defect. | ||
| M13973 | AZD9567 | GCR |
| AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation. | ||
| M28820 | AZ-PFKFB3-67 | PFKFB3 |
| AZ-PFKFB3-67 is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively. | ||
| M29932 | AZ10397767 | CXCR |
| AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC50 of 1 nM. AZ10397767 attenuates the Oxaliplatin-induced NF-κB transcriptional activity and potentiates Oxaliplatin-induced apoptosis in androgen-independent prostate cancer (AIPC) cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo. | ||
| M31070 | AZ-PFKFB3-67 quarterhydrate | PFKFB3 |
| AZ-PFKFB3-67 quarterhydrate is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively. | ||
| M31413 | AZ-67 | PFKFB3 |
| AZ-67 is an inhibitor of PFKFB3 as well as glycolysis and can be used in studies related to neurodegenerative diseases. | ||
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