About 32 results found for searched term "ARC7" (0.116 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1705 | Erlotinib Hydrochloride | EGFR/HER2 |
| Tarceva, CP-358774, OSI-774, NSC-718781 | ||
| Erlotinib is an inhibitor of human EGFR tyrosine kinase (IC50 = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC50 = 20 nM). | ||
| M3925 | Arctiin | Others |
| Arctii; NSC 315527; Arctigenin-4-glucoside | ||
| Arctiin is an active lignin isolated from Arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. | ||
| M41098 | ARC7 | Antibiotic |
| ARC7 can act as a probe for secondary metabolism in S. | ||
| M2104 | BYL-719 | PI3K |
| Alpelisib; BYL719 | ||
| Alpelisib (Byl-719) is an effective, selective PI3Kα inhibitor with oral activity. Alpelisib (Byl-719) was targeted to PIK3CA mutated carcinoma. The IC50 of Alpelisib (Byl-719) against P110 α, P110 γ, p110δ and P110 β were 5 nM, 250 nM, 290 nM and 1200 nM, respectively. It has antitumor activity. | ||
| M3244 | Metformin | AMPK |
| 1,1-Dimethylbiguanide | ||
| Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. | ||
| M4572 | Limonin | JAK |
| Limonoic acid 3,19:16,17 dilactone | ||
| Limonin is a potent inhibitor of CYP3A4 with an IC50 of 6.2 μM. Limonin inhibits HIV-1 with an EC50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC50 of 54.74 μM. Limonin, a triterpenoid rich in citrus fruits, has antiviral and anti-tumor activities. | ||
| M4621 | Garcinone-C | ATM/ATR |
| Garcinone C is a xanthone derivative, a natural compound extracted from Garcinia oblongifolia Champ. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while effectively inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, CDC2, Stat3 and CDK7. | ||
| M4775 | Gambogic-acid | Bcl-2 |
| Beta-Guttiferrin | ||
| Gambogic Acid (beta-Guttiferrin) a Gambogic resin from the Garcinia Hanburyi tree. Gambogic Acid (beta-guttiferrin) inhibited bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and McL-1 with IC50 values of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, respectively. 1.06 μM and 0.79 μM. | ||
| M7792 | EF-24 | ERK |
| EF24 | ||
| EF-24 is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. | ||
| M8189 | STF-62247 | Autophagy |
| STF62247; STF 62247 | ||
| Stf-62247 is an autophagy inducer with selective cytotoxicity against VHL-deficient renal cell carcinoma, with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. Stf-62247 can trigger ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M9897 | GB1107 | Galectin |
| GB-1107 | ||
| GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules. | ||
| M11128 | Segetalin C | Antibiotic |
| Cyclopeptide (compound VIII) has good activity against pathogenic fungi Candida albicans and dermatophytes, in addition to high cytotoxicityagainst Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines with CTC50 values of 3.35 and 5.72 micromol/L. | ||
| M11348 | Garcinol | AChR/AChE |
| Garcinol is a kind of polyisoprene diphenylketone extracted from Garcinia japonicum. It has anticholinesterase properties for AChE and butyrylcholinesterase (BChE) with IC50 of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibited histone acetyltransferases (HATs, IC50=7 μM) and P300 /CPB related factors (PCAF, IC50=5 μM). Garcinol has anti-inflammatory and anticancer activities. | ||
| M11495 | Recombinant Human TNF-α (E. coli) | Cytokines and Growth Factors |
| TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin | ||
| Recombinant human TNF-α protein (E. coli) is a homotrimer with a subunit molecular mass of 17.3 kDa. TNF-a plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases; and in viral, bacterial, fungal, and parasitic infections. ED50 < 30.0 pg/ml, measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D, corresponding to a specific activity of > 3.3 × 107 units/mg. | ||
| M13433 | NVP-DKY709 | Others |
| NVP-DKY709 is a potent and effective (IKAROS Family Zinc Finger 2, IKZF2) inhibitor that contributes to cancer research.DKY709 acts as a CRBN binder to induce the formation of the CRBN-DKY709-IKZF2 ternary complex. This ternary complex promotes the ubiquitination and degradation of IKZF2. | ||
| M15041 | Recombinant Human MEC/CCL28 (E. coli) | Cytokines and Growth Factors |
| Chemokine (C-C motif) ligand 28; CCL-28; SCYA28 | ||
| CCL28 (CC chemokine ligand 28), a novel CC chemokine, was identified by TBLASTN search using the human Genome System (HGS) and Genbank dbEst databases using a consistent sequence of human chemokines. Protein structure: CCL28 (Ser20-Tyr127), Accession # ：Q9NRJ3. | ||
| M19981 | Recombinant Rat MIP-3 α/CCL20 (HEK 293) | Cytokines and Growth Factors |
| CCL-20; CKb4; Exodus; LARC; MIP-3-alpha | ||
| Macrophage inflammatory protein-3 (MIP-3α), also known as chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC), is a small cytokine in the CC chemokine family. Accession P97884 - # 1. | ||
| M20830 | GYY4137 | STAT |
| GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity. | ||
| M24803 | Larcaviximab | Anti-infection |
| c4G7-N | ||
| Larcaviximab (c4G7-N) is an IgG1 kappa anti-Ebola virus glycoprotein chimeric monoclonal antibody. | ||
| M24913 | Spesolimab | IL Receptor/Related |
| BI 655130 | ||
| Spesolimab (BI 655130) is an anti-IL-36R antibody. IL-36 involves in immune system, as Spesolimab can be used for palmoplantar pustulosis (PPP) research. Spesolimab is associated with the reduction of biomarkers linked to innate, Th1/Th17, and neutrophilic pathways. | ||
| M27737 | NSC 140873 | Others |
| NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335). | ||
| M28023 | GSK2239633A | CCR |
| GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11. | ||
| M28645 | Azilsartan mepixetil | Angiotensin Receptor |
| Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A). | ||
| M28940 | Befotertinib | EGFR/HER2 |
| D-0316 | ||
| Befotertinib (D-0316) is the third-generation EGFR tyrosine kinase inhibitor. Befotertinib can be used for the research of EGFR T790M-positive non-small cell lung cancer (NSCLC). | ||
| M29088 | SGC-SMARCA-BRDVIII | Epigenetic Reader Domain |
| SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts. | ||
| M29282 | KRP-297 | PPAR |
| MK-0767 | ||
| KRP-297 is a PPARα and PPARγ agonist potentially for the research of type 2 diabetes and dyslipidemia. KRP-297 restores reduced lipid oxidation, and inhibits of enhanced lipogenesis and triglyceride accumulation in the liver. | ||
| M30819 | Isogambogenic acid | Others |
| Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC50 values of 0.4327-5.942 μmol/L. | ||
| M38635 | 1,4,6-Trihydroxy-5-methoxy-7-prenylxanthone | Antibiotic |
| 1,4, 6-trihydroxy-5-methoxy-7-prenylxanthone is an antimicrobial agent that can be isolated from the genus garcinia. 1,4, 6-trihydroxy-5-methoxy-7-prenylxanthone inhibits S. aureus and B. cereus with MIC values of 128 μg/mL and 200 μg/mL, respectively. | ||
| M38817 | 7-Methoxy-1-tetralone | Apoptosis |
| 7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. | ||
| M38850 | β-Ionone | Apoptosis |
| β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity. | ||
| M45400 | ACBI2 | PROTAC |
| ACBI2 is a potent, orally active VHL PROTAC SMARCA2 degrader (EC50: 7 nM) that degrades SMARCA2 (DC50: 1 nM in RKO cells).ACBI2 can be used in lung cancer research. | ||
| M49925 | (10E,12Z)-octadeca-10,12-dienoic acid | Others |
| (10E,12Z)-octadeca-10,12-dienoic acid is an octadecadienoic acid with anticancer activity that inhibits proliferation, nuclear division, colony formation and cellular DNA synthesis in gastric adenocarcinoma cells (SGC-7901). | ||
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