About 2 results found for searched term "AMD 3465" (0.083 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2381 | AMD3465 hexahydrobromide (AMD3465 ) | CXCR |
| GENZ-644494 hexahydrobromide | ||
| AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication. | ||
| M59298 | AMD 3465 | CXCR |
| GENZ-644494 | ||
| AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4. AMD 3465 inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50 = 1-10 nM). AMD 3465 inhibits CXCL-12-induced growth in U87 and Daoy cells. | ||
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