About 25 results found for searched term "ALK2-IN-2" (0.143 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14942 | ALK2-IN-2 | TGF-β Receptor |
| ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3. | ||
| M2550 | SB-505124 | TGF-β Receptor |
| Sb-505124 is a selective inhibitor of TGF-βI receptor (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. Sb-505124 also inhibits ALK7, but not ALK1, 2, 3 and 6. | ||
| M2647 | DMH1 | ALK |
| dorsomorphin homolog 1 | ||
| DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. | ||
| M3889 | LDN-214117 | ALK |
| LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM and >100 fold selectivity for ALK5. | ||
| M4240 | Shikonin | TNF Receptor |
| C.I. 75535; Isoarnebin 4; CAS# 54952-43-1 | ||
| Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. | ||
| M4520 | (+)-Corydaline | AChR/AChE |
| (+)-Corydaline; Corydalin | ||
| Corydaline ((+) -corydaline) is an isoquinoline alkaloid extracted from Corydalis Yanhusuo. It is an inhibitor of AChE with IC50 of 226 µM. Corydaline is a μ-opioid receptor agonist (Ki = 1.23 µM) that inhibits the replication of enterovirus 71 (EV71) (IC50 = 25.23 µM). Corydaline has anti-angiogenesis, anti-allergy, gastric emptying and anti-nociception effects. | ||
| M4594 | Cytisine | AChR/AChE |
| Cytisine; Sophorine; Baptitoxine | ||
| Cytisinicline (Cytisine) is an alkaloid that can be extracted from Laburnum and Cytisus. Cytisinicline (Cytisine) is a partial agonist of α4β2 nicotinic acetylcholinergic receptors (α4β2 nAChRs), and also a partial agonist of α4β2 and α7 receptors. It has been used medically to help people quit smoking. | ||
| M14488 | DIPQUO | Phosphatase |
| DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β. | ||
| M14877 | ALK inhibitor 1 | ALK |
| ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). | ||
| M18992 | Trigonelline | Metabolite/Endogenous Metabolite |
| Trigenolline | ||
| Trigonelline, an alkaloid with potential antidiabetic activity, is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells. | ||
| M20633 | TP0427736 HCl | Src-bcr-Abl |
| TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. | ||
| M25078 | Nemvaleukin alfa | IL Receptor/Related |
| ALKS 4230; RDB-1450 | ||
| Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer. | ||
| M28040 | ALK4290 | CCR |
| AKST4290 | ||
| ALK4290 (AKST4290) is a potent and orally active CCR3 inhibitor, with a Ki of 3.2 nM for hCCR3. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism. | ||
| M28745 | OD36 | RIPK |
| OD36 is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with KDs of 37 nM. | ||
| M28756 | JH-VIII-157-02 | ALK |
| JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. | ||
| M29383 | TL13-12 | PROTAC |
| TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 and the Cereblon ligand of Pomalidomide. | ||
| M29384 | TL13-112 | PROTAC |
| TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib and the Cereblon ligand of Pomalidomide. | ||
| M29459 | ZX-29 | ALK |
| ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. | ||
| M29632 | M4K2234 | ALK |
| M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer. | ||
| M29975 | SB-505124 hydrochloride | TGF-β Receptor |
| SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6. | ||
| M30909 | Chaetominine | PI3K |
| (-)-Chaetominine | ||
| Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated agent resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells. | ||
| M31274 | NH2-C2-amido-C2-Boc | PROTAC Linker |
| NH2-C2-amido-C2-Boc is a PROTAC linker, which refers to the alkyl/ether composition. NH2-C5-NH-Boc can be used in the synthesis of a series of PROTACs, such as the PROTAC CDK2/9 Degrader-1. | ||
| M40101 | Solasurine | Others |
| Solasurine is a steroidal alkaloid that can be isolated from Solanum surrattence. Solasurine can interact with the C3-like protease (SARS-CoV-2 main protease) amino acids Phe8, Pro9, Ile152, Tyr154, Pro293, Phe294, Val297, and Arg298. | ||
| M43471 | ALK2-IN-5 | ALK |
| ALK2-IN-5, pyrazolopyrimidine compound, is an ALK2 inhibitor. | ||
| M49566 | Itacnosertib | JAK |
| Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871. | ||
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