About 13 results found for searched term "80-78-4" (0.053 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6257 | ONC212 | Apoptosis |
| TR-31 | ||
| The ClpP activator ONC‐212 (TR‐31), a fluorinated-ONC201 analogue, is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity. | ||
| M7988 | 5Z-7-Oxozeaenol | Others |
| FR148083; L783279; LL-Z 1640-2 | ||
| 5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50 = 80 nM), TAK1 (MEKK7), MKK7, and MEK1, which all contain a common cysteine residue in the ATP-binding site. | ||
| M9176 | DTP3 | JNK |
| DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway. | ||
| M10886 | Samuraciclib hydrochloride | CDK |
| Samuraciclib (ICEC0942, CT7001) is a novel oral CDK7 inhibitor with an IC50 of 40 nM. It has IC50 values for other CDK proteins such as CDK1, CDK2, CDK5 and CDK9 as 45, 15, 230 and 30 times higher than that of CDK7 IC50, respectively. ICEC0942 (CT7001) promotes cell cycle blocking and apoptosis. | ||
| M11535 | RG7800 | DNA/RNA Synthesis |
| RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247 | ||
| RG7800 is a small molecule SMN2 splicing modifier. RG7800 has the potential to be used in spinal muscular atrophy. RG7800 corrects selective splicing of the human SMN2 gene in the brain of a transgenic SMA model mouse, leading to an increase in SMN protein in the brain. | ||
| M14033 | Ro 64-6198 | Opioid Receptor |
| Ro 64-6198 is a potent, selective, nonpeptide, high-affinity, high cellular permeability and brain penetration N/OFQ receptor (NOP) agonist with an EC50 value of 25.6 nM. | ||
| M19262 | Solanidine | Others |
| Solanidine is a cholestane alkaloid isolated from several potato species including Solanum demissum, Solanum acaule, and Solanum tuberosum. Solanidine can inhibit proliferation and exhibit obvious antitumor effect. | ||
| M24815 | Efgivanermin alfa | Others |
| Efgivanermin alfa is an active peptide. Efgivanermin alfa can be used for various biochemical studies. | ||
| M29308 | SB-277011 | Dopamine Receptor |
| SB-277011A | ||
| SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant. IC50 value: 8.0 (pKi) Target: D3 receptor | ||
| M31061 | Vimirogant hydrochloride | ROR |
| VTP-43742 hydrochloride | ||
| Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. | ||
| M40747 | Belapectin | Galectin |
| GR-MD-02 | ||
| Belapectin, a galectin 3 inhibitor with a Ki value of 2.8 μM, reduces hepatic fibrosis and portal hypertension in rats, and can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M40756 | Plazomicin Sulfate | Antibiotic |
| Plazomicin Sulfate is a derivative of Sisomicin and a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis in a concentration-dependent manner, with broad-spectrum antimicrobial activity against aerobic Gram-negative bacteria, and can be used in studies related to pyelonephritis. | ||
| M52426 | Mca-SEVNLDAEFK(Dnp) | Gamma-secretase/Beta-secretase |
| Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. | ||
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