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5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50 = 80 nM), TAK1 (MEKK7), MKK7, and MEK1, which all contain a common cysteine residue in the ATP-binding site. 5Z-7-oxozeaenol has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.
| Molecular Weight | 362.37 |
| Formula | C19H22O7 |
| CAS Number | 253863-19-3 |
| Solubility (25°C) | DMSO: ≥10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Jiaquan Wu, et al. Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol
[4] Ulyana Muoz Acua, et al. Effects of (5Z)-7-oxozeaenol on the oxidative pathway of cancer cells
[5] Ulyana Muoz Acua, et al. Effects of (5Z)-7-oxozeaenol on MDA-MB-231 breast cancer cells
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