About 11 results found for searched term "65-19-0" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4593 | Yohimbine-Hydrochloride | Adrenergic Receptor |
| YHB Hydrochloride | ||
| Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. | ||
| M40625 | Zelasudil | ROCK |
| RXC-007 | ||
| Zelasudil (RXC-007) is a selective ROCK2 inhibitor for studies related to idiopathic pulmonary fibrosis. | ||
| M51575 | p60c-src Substrate | Others |
| p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). | ||
| M55880 | (Rac)-Lisaftoclax | Bcl-2 |
| (Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research. | ||
| M10937 | Edicotinib | CSF-1R (c-Fms) |
| JNJ-40346527; JNJ-527 | ||
| Edicotinib (JNJ-40346527) is a potent, selective, blood-brain permeable and orally active CSF-1R inhibitor.IC50 3.2 nM. Edicotinib has less inhibitory effect on KIT and FLT3,IC50 The values are 20 nM and 190 nM, respectively. Edicotinib inhibits the expansion of microglia, weakens the proliferation of microglia and neurodegenerative degeneration. Edicotinib can be used in the study of Alzheimer's disease and rheumatoid arthritis. | ||
| M24734 | Risankizumab | IL Receptor/Related |
| zz rzaa; BI 655066 | ||
| Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis. | ||
| M27921 | BI 653048 | GCR |
| BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus. | ||
| M27922 | BI 653048 phosphate | GCR |
| BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 phosphate inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 phosphate is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus. | ||
| M28491 | MRT199665 | Salt-inducible Kinase |
| MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370. | ||
| M30052 | GW3965 | Liver X Receptor |
| GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively. | ||
| M39113 | Cyclo(Pro-Leu) | Metabolite/Endogenous Metabolite |
| Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer. | ||
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