About 10 results found for searched term "54-36-4" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1427 | Lacosamide | Sodium Channel |
| Erlosamide | ||
| Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. | ||
| M5786 | Metyrapone | Metabolite/Endogenous Metabolite |
| Metapirone; Su-4885 | ||
| Metyrapone (Metapirone) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone (Metapirone) inhibits cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. | ||
| M55229 | BDE-47 | Apoptosis |
| 2,2',4,4'-tetrabromodiphenyl ether | ||
| BDE-47 is an apoptosis inducer involving ROS mediated mitochondrial pathway and Nrf2 pathway activation. BDE-47 reduced cell viability and disrupted mitochondrial dynamics by inhibiting mitochondrial fusion and fission simultaneously, leading to MMP decreases, ROS overgeneration, ATP depletion, and cellular disintegration in a dose-dependent manner. | ||
| M2423 | AZD7545 | PDK1 |
| AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. | ||
| M6434 | AMG 548 | Casein Kinase |
| AMG 548 is an orally potent and selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM) and >1000-fold selective for p38γ and p38δ. In addition, AMG 548 also potently inhibited whole blood LPS-stimulated TNFα (IC50=3 nM) and inhibited Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
| M27689 | PF-03654746 Tosylate | Histamine Receptor |
| PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD). | ||
| M30935 | PF-03654746 | Histamine Receptor |
| PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis. PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD). | ||
| M45284 | AMG-548 dihydrochloride | p38 MAPK |
| AMG-548 dihydrochloride is an orally active, selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM), and >1000-fold selective for p38γ and p38δ. AMG-548 dihydrochloride also potently inhibits whole blood LPS-stimulated TNFα (IC50=3 nM). LPS-stimulated TNFα (IC50=3 nM). In addition, AMG-548 dihydrochloride inhibits Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
| M56527 | PHA-543613 hydrochloride | AChR/AChE |
| PHA-543613 hydrochloride is an oral or active α7 nAChR agonist with brain permeability, For α3β4, α1β1γδ, α4β2 and 5-HT3 receptors selective. | ||
| M56321 | Z62954982 | Ras |
| Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (IC50=50 μM). | ||
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