About 2 results found for searched term "423-55-2" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8392 | Tirapazamine | Apoptosis |
| SR259075; SR4233; Win59075; SML 0552; Tirazone; TPZ | ||
| Tirapazamine (TPZ，SR-4233, WIN 59075) is the first hypoxia-activated prodrug. Tirapazamine kills hypoxic cells by inducing chromosome aberrations and DNA double-strand breaks. Tirapazamine induced cell cycle arrest and apoptosis, and down-regulated HIF-1α, CA-IX and VEGF expression. | ||
| M29964 | SB-423557 | Calcium-sensing Receptor |
| SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation. | ||
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