About 1 result found for searched term "1914989-49-3" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29016 | BPN-15606 | Gamma-secretase/Beta-secretase |
| BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance. | ||
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